ArticleFrontiers in molecular biosciences2026
Transcriptional regulatory network analysis identifies conserved cis-antisense ncRNAs in the vancomycin and ceftriaxone stress response of
Article in Frontiers in molecular biosciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: Methods: Here, we analyzed RNA-seq profiles of Results: Both antibiotics activated a substantial shared response dominated by envelope remodeling/proteostasis and bioenergetic-nucleotide economy, while vancomycin recruited a broader condition-specific program. Despite differing scale (Van-TRN: 533 nodes/587 edges; Cef-TRN: 375 nodes/431 edges), both networks displayed sparse, hub-centered hierarchies and strong nesting, with ∼90% of ceftriaxone regulation contained within the vancomycin scaffold. From the shared ncRNA layer, we prioritized two inducible Conclusion: Together, these results provide an integrated TRN framework that connects network rewiring to conserved ncRNA-centered candidate control during vancomycin and ceftriaxone stress responses, prioritizing testable ncRNA regulons for downstream functional validation.
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