Evidence map›Paper›PMID 42344114›Full record

ArticleAdvanced functional materials2022

Rationally designed anisotropic and auxetic hydrogel patches for adaptation to dynamic organs.

Parth Chansoria, John Blackwell, Emma L Etter, Emily E Bonacquisti, Natalie Jasiewicz, Taylor Neal, Sarah Alhajli Kamal, Jiaul Hoque, Shyni Varghese, Thomas Egan and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced functional materials, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Review
  5. Soft and Adhesive Cardiac Patch for Electrophysiological and Contraction Measurement.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  6. Review
  7. Article
  8. Article
  9. Review
  10. Review
  11. Article
  12. Article
  13. Lithography-based 3D printing of hydrogels.Nature reviews bioengineering · 2025
    Article
  14. Article
  15. Review
  16. Review
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Parth ChansoriaDivision of Pharmacoengineering and Molecular Pharmaceutics, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
John BlackwellDivision of Cardiothoracic Surgery, Department of Surgery, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Emma L EtterDivision of Pharmacoengineering and Molecular Pharmaceutics, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Emily E BonacquistiDivision of Pharmacoengineering and Molecular Pharmaceutics, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Natalie JasiewiczDivision of Pharmacoengineering and Molecular Pharmaceutics, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Taylor NealDivision of Pharmacoengineering and Molecular Pharmaceutics, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Sarah Alhajli KamalDivision of Pharmacoengineering and Molecular Pharmaceutics, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Jiaul HoqueDepartment of Orthopaedic Surgery, School of Medicine, Duke University, Durham, NC, 27710, USA.
Shyni VargheseDepartment of Orthopaedic Surgery, School of Medicine, Duke University, Durham, NC, 27710, USA.
Thomas EganDivision of Cardiothoracic Surgery, Department of Surgery, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Juliane NguyenDivision of Pharmacoengineering and Molecular Pharmaceutics, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

Funding

RNA EXO-Codes: A novel way to reprogram pathological exosomesR01EB023262 · NIBIB · UNIV OF NORTH CAROLINA CHAPEL HILL · PI NGUYEN, JULIANE · 2017 to 2020
$1.7M
Antibody Fragments as Biochemical Tools to Interrogate CD9 Function in Inflammatory DiseasesR21GM135853 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI NGUYEN, JULIANE, WOHLFERT, ELIZABETH · 2020 to 2021
$433k
NIBIB NIH HHS R01 EB023262NIGMS NIH HHS R21 GM135853
6 · The paper itself

Abstract

Current hydrogel or fabric patches for organ repair are generally not designed to conform to the complex mechanics of dynamic organs such as the lung or heart. This work presents a new, biocompatible and bilayered, hydrogel-based patch platform, consisting of a non-fouling top layer and a cell adhesive bottom layer, that caters to the anisotropic and auxetic characteristics of dynamic organs. Integrated computational and experimental studies were used to screen over 116 unique anisotropic-auxetic architectures to establish design rules and tailor the patches to a broad range of target organ dynamics. The patches were then validated in

Indexed as

anisotropicauxeticbiomimeticfluid leakagehydrogelspatchpuncture wound

Identifiers

PMID42344114
PMCPMC13289614

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.