Evidence map›Paper›PMID 42344107›Full record

ArticleJAMIA open2026

Development of the authentication and authorization processes for the iAgree portal, a platform for patient-controlled data sharing across health systems.

Spencer L Soohoo, Michelle Sophie Keller, Yunan Chen, Di Hu, Shao-Chi Huang, Tsung-Ting Kuo, Chloe Leder, Xi Lu, Daniela Meeker, Brad Morse and 8 more

Abstract read
In one paragraph

Article in JAMIA open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Spencer L SoohooEnterprise Information Systems, Cedars-Sinai Medical Center, Los Angeles, CA, 90048, United States.
Michelle Sophie KellerLeonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, 90089, United States.ORCID https://orcid.org/0000-0002-8157-7586
Yunan ChenDepartment of Informatics, Donald Bren School of Information and Computer Sciences, University of California, Irvine, CA, 92697, United States.
Di HuDepartment of Informatics, Donald Bren School of Information and Computer Sciences, University of California, Irvine, CA, 92697, United States.
Shao-Chi HuangEnterprise Information Systems, Cedars-Sinai Medical Center, Los Angeles, CA, 90048, United States.
Tsung-Ting KuoDepartment of Biomedical Informatics and Data Science, Yale School of Medicine, New Haven, CT, 06510, United States.
Chloe LederLeonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, 90089, United States.
Xi LuDepartment of Information Science, University at Buffalo, New York, NY, 14260, United States.
Daniela MeekerDepartment of Biomedical Informatics and Data Science, Yale School of Medicine, New Haven, CT, 06510, United States.ORCID https://orcid.org/0000-0002-1034-7628
Brad MorseDivision of General Internal Medicine, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, 80045, United States.
Harold MoyseEnterprise Information Systems, Cedars-Sinai Medical Center, Los Angeles, CA, 90048, United States.
Gayathri NagarajDepartment of Biomedical Informatics and Data Science, Yale School of Medicine, New Haven, CT, 06510, United States.
An T NguyenDepartment of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, 90048, United States.
Lisa M SchillingDepartment of Surgery, Yale School of Medicine, New Haven, CT, 06520, United States.
Andrey SoaresDivision of General Internal Medicine, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, 80045, United States.ORCID https://orcid.org/0000-0003-4319-9411
Mary A WhooleyDepartment of Medicine, University of California, San Francisco, CA, 94143, United States.
Kai ZhengDepartment of Informatics, Donald Bren School of Information and Computer Sciences, University of California, Irvine, CA, 92697, United States.
Lucila Ohno-MachadoDepartment of Biomedical Informatics and Data Science, Yale School of Medicine, New Haven, CT, 06510, United States.ORCID https://orcid.org/0000-0002-8005-7327

Funding

iAGREE: A Multi-Center, Networked Patient Consent StudyR01HG011066 · NHGRI · YALE UNIVERSITY · PI OHNO-MACHADO, LUCILA · 2020 to 2024
$4.2M
SOCAL: Privacy-protecting Sharing Of Clinical Data Across LaboratoriesR01EB031030 · NIBIB · YALE UNIVERSITY · PI KUO, TSUNG-TING · 2022 to 2025
$1.3M
NHGRI NIH HHS R01 HG011066NIBIB NIH HHS R01 EB031030
6 · The paper itself

Abstract

Objective: To develop the authentication and authorization module for iAgree, a privacy-preserving platform that enables patients to manage consent preferences and share electronic health record (EHR) data across multiple health systems with researchers. The consent and blockchain modules are described elsewhere. Materials and Methods: We developed the authentication and authorization module of iAgree. This module supports account creation and cross-institution identity binding as part of the iAgree workflow to enable patients to authenticate using federated credentials (eg, Google, Facebook). Patients link their identities across institutions by signing into each participating health system's patient portal. Identity attributes retrieved via a Fast Healthcare Interoperability Resources (FHIR Results: We installed the iAgree platform in a test or proof-of-concept environment at three health systems: Cedars-Sinai Medical Center, University of Colorado, and University of California, San Francisco. Functional testing with test patients demonstrated that authentication, identity binding, and secure multi-site record linkage could safely bind the identities of patients across sites, enabling patients to manage their data sharing consent preferences. Discussion: The results demonstrate the feasibility of a privacy-preserving multi-institutional data-sharing architecture that employs federated login, secure privacy-preserving multi-site record linkage, and blockchain-based consent tracking to align with privacy regulations while increasing transparency and patient autonomy. Conclusion: This effort demonstrated that the authentication and authorization module enables iAgree to be a feasible and secure platform for patient-directed sharing of EHR data across health systems with researchers. Future work will evaluate usability, patient engagement, and future real-world deployment.

Indexed as

blockchaindata sharingelectronic health recordsfederated identityinformed consentpatient portalsprivacy

Identifiers

PMID42344107
PMCPMC13289608

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.