ArticleNan fang yi ke da xue xue bao = Journal of Southern Medical University2026
[Overexpressing NDUFA13 and CRIP1 improves B cell injury and lung Lesions in COPD mouse models].
Article in Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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7 authors.
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Abstract
objectivesTo identify B cell-associated biomarkers in chronic obstructive pulmonary disease (COPD) using bioinformatics and explore their diagnostic and therapeutic potential.
methodsBased on the GEO database, differential expression analysis, WGCNA, scRNA-seq, ROC curve analysis, and Mendelian randomization analysis were performed to screen B cell-related biomarkers. Twenty ICR mice were divided equally into control and COPD groups, and COPD model was established using lipopolysaccharide (LPS) combined with cigarette smoke exposure to verify biomarker expression. Cultured murine B lymphoma CH12.LX cells were stimulated with 1 μg/mL LPS and transfected with plasmids overexpressing CRIP1 or NDUFA13 or with a negative control plasmid, and the changes in protein expressions of NDUFB8, MTCO1, ATP5A and ACTB were examined with Western blotting. CCK-8 assay and flow cytometry were used to analyze the viability and apoptosis of murine lung epithelial cells co-cultured with the treated CH12.LX cells, respectively.
resultsTwo protective factors, namely NDUFA13 (OR=0.2598) and CRIP1 (OR=0.2690;
conclusionsNDUFA13 and CRIP1 are B cell-associated protective biomarkers in COPD with potential diagnostic values for COPD.
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