ReviewCurrent opinion in HIV and AIDS2026
Implications of HIV persistence and pathogenesis in microglia.
Review in Current opinion in HIV and AIDS, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
purpose of the reviewThis review summarizes recent advances in understanding HIV infection of the brain, focusing on viral persistence in microglia and associated pathogenesis during viremia and viral suppression. We highlight key findings in microglial research that inform the next steps toward therapeutic strategies and cure approaches addressing the brain as a viral reservoir. RECENT
findingsMicroglia can contain intact, replication-competent inducible proviruses, even during antiretroviral therapy (ART). The microglial chromatin context and HIV integration site landscape during HIV infection are reportedly distinct from peripheral lymphocytes. Upon infection, both infected and bystander microglia exhibit pro-inflammatory and senescent phenotypes that closely resemble those observed in aging microglia and play a central role in neuropathogenesis. ART mitigates these effects but does not fully restore to levels observed in HIV-uninfected conditions. SUMMARY: Microglial HIV infection and persistence of this reservoir play a central and detrimental role in HIV pathogenesis in the brain. Given their role in neurodegeneration during HIV infection, closer characterization of the microglial (latent) reservoir and careful monitoring of neurodegeneration during treatment and cure interventions are essential. Treatment and cure strategies should prioritize minimizing viral transcription and protein expression within the brain reservoir to mitigate neuroinflammation and neuropathogenesis.
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