ArticleThe Journal of international medical research2026
Integration of single-cell cis-expression quantitative trait locus and Mendelian randomization analyses identifies a Treg-specific gene for precision therapy in rheumatoid arthritis, gonarthrosis, and gouty arthritis.
Article in The Journal of international medical research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
ObjectiveArthritis, including rheumatoid arthritis, gonarthrosis, and gouty arthritis, poses a substantial public health challenge. Regulatory T cells are critical for immune homeostasis, and their dysfunction contributes to arthritis pathogenesis; however, the specific gene regulatory programs causally influencing disease susceptibility remain elusive. We aimed to identify regulatory T cell-specific therapeutic targets using single-cell cis-expression quantitative trait locus and Mendelian randomization.MethodsWe integrated single-cell regulatory T cell cis-expression quantitative trait locus data with genome-wide association study results from FinnGen R12 (16,314 rheumatoid arthritis, 61,356 gonarthrosis, and 12,342 gouty arthritis cases). Two-sample Mendelian randomization was employed to infer causality, using the inverse-variance weighted method, with rigorous sensitivity analyses conducted to ensure robustness.ResultsThe analysis revealed distinct causal associations. In rheumatoid arthritis, upregulation of DexD/H-box helicase 60 like (
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