Cell proliferation and differentiation during epidermis renewal.

Kai Liu, Kaidi Ren, Dengwen Li, Yang Yang

Abstract readReview

In one paragraph

Review in Journal of Zhejiang University. Science. B, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Kai LiuDepartment of Translational Medicine Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.

Kaidi RenDepartment of Pharmacy, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.

Dengwen LiDepartment of Genetics and Cell Biology, State Key Laboratory of Medicinal Chemical Biology, College of Life Sciences, Nankai University, Tianjin 300071, China. fccyangyang430@zzu.edu.cn, dwli@nankai.edu.cn.

Yang YangDepartment of Translational Medicine Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China. fccyangyang430@zzu.edu.cn.

Funding

the National Key R&D Program of China 2021YFA1101001the National Natural Science Foundation of China 82204389 and 82470403

6 · The paper itself

Abstract

Residing at the outermost layer of the skin, the epidermis is composed of stratified squamous epithelial cells. Regular renewal of the epidermis is essential for maintaining its barrier function, which is dependent on the orchestrated proliferation and differentiation of stem cells located in the basal epidermis. This process necessitates precise dual regulation through the intrinsic control of cell division orientation and external microenvironmental influences. In this comprehensive review, we delve into the critical processes underlying epidermis renewal, emphasizing the balance between symmetric and asymmetric cell fate and the integration of differentiated cells into the suprabasal layer. Our paper highlights the pivotal roles of single-cell omics, live imaging, and artificial intelligence (AI)-driven modeling techniques in elucidating the molecular mechanisms governing cell proliferation and differentiation during epidermis renewal.

Indexed as

Cell DifferentiationCell ProliferationEpidermal CellsEpidermisAnimalsArtificial IntelligenceCell DivisionHumansStem CellsAsymmetric cell divisionBasement membrane dynamicsEpidermis renewalMechanotransductionSingle-cell omicsStem cell proliferation

Identifiers

PMID42343634

DOI10.1631/jzus.B2500085

PMCPMC13294290

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.