ReviewStem cell research & therapy2026
Mapping the evolutionary landscape of intestinal organoids: from self-organization biology to precision medicine.
Review in Stem cell research & therapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The advent of intestinal organoids has fundamentally transformed biomedical research by providing a physiological ex vivo model that recapitulates native tissue architecture. Despite an exponential surge in publications, a comprehensive mapping of the field's evolutionary trajectory remains lacking. This study employs bibliometric analysis to dissect the global landscape of intestinal organoid research from 1986 to 2025, utilizing data from the Web of Science Core Collection. By leveraging VOSviewer and bibliometrix tools, we demonstrate that while the USA dominates in publication quantity, the Netherlands commands the highest citation influence, reflecting the enduring legacy of foundational works by Sato and Clevers. Co-citation and keyword trend analyses demonstrate evolving research priorities. The field initially focused on stem cell differentiation and culture optimization, then expanded into disease modeling of colorectal cancer and inflammatory bowel disease. Notably, recent burst detection identifies a clear pivot towards "organ-on-a-chip" technology, "mechanobiology," and "single-cell sequencing". These hotspots signal the advent of precision engineering. Bioengineering and high-throughput omics together drive the development of next-generation physiologically relevant intestinal models. Ideally, this bibliometric blueprint serves as a navigational guide for researchers, highlighting the paradigm shift towards complex, engineered micro-physiological systems (MPS) as the future of intestinal research.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.