ArticleJournal of neuroinflammation2026
IRF7 deficiency in myeloid cells results in increased disease severity and death during alphavirus encephalomyelitis despite intact expression of type I interferons.
Benjamin H Nguyen, Elise Stanley, Wanmin Dai, Elizabeth M Troisi, Diane E Griffin
Abstract read
In one paragraphArticle in Journal of neuroinflammation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
5 authors.
Benjamin H NguyenW. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, 615 N Wolfe St, MD, 21205, Baltimore, USA. bhnguyen@jhmi.edu.ORCID http://orcid.org/0000-0002-8603-4046 Elise StanleyW. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, 615 N Wolfe St, MD, 21205, Baltimore, USA.
Wanmin DaiW. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, 615 N Wolfe St, MD, 21205, Baltimore, USA.
Elizabeth M TroisiW. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, 615 N Wolfe St, MD, 21205, Baltimore, USA.
Diane E GriffinW. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, 615 N Wolfe St, MD, 21205, Baltimore, USA.
Funding
Training: Molecular & Cellular Bases of Infectious DiseasesT32AI007417 · NIAID · JOHNS HOPKINS UNIVERSITY · PI Arturo Casadevall · 1994 to 2026
$11.9MCONTROL OF ALPHAVIRUS REPLICATION IN THE NERVOUS SYSTEMR01NS038932 · NINDS · JOHNS HOPKINS UNIVERSITY · PI GRIFFIN, DIANE E · 2001 to 2016
$4.9MRole of CD4 T cells in fatal alphavisus encephalomyelitisR01NS087539 · NINDS · JOHNS HOPKINS UNIVERSITY · PI GRIFFIN, DIANE E · 2014 to 2018
$1.9MRole of the nsP3 macrodomain in alphavirus virulenceR56AI137264 · NIAID · JOHNS HOPKINS UNIVERSITY · PI GRIFFIN, DIANE E, LEUNG, ANTHONY K L · 2019 to 2019
$818kNIAID NIH HHS R56 AI137264NIAID NIH HHS T32 AI007417NINDS NIH HHS R01 NS038932NINDS NIH HHS R01 NS087539
6 · The paper itselfAbstract
Alphaviruses are arthropod-borne pathogens that cause immune-mediated encephalomyelitis. The prototypic alphavirus, Sindbis virus (SINV), primarily infects neurons in mice, resulting in neurologic disease involving both the brain and spinal cord. Interferon (IFN) regulatory factor (IRF) 7-deficient mice (Irf7
Indexed as
Alphavirus InfectionsEncephalomyelitisInterferon Regulatory Factor-7Interferon Type IMyeloid CellsAnimalsInterferon-alphaMiceMice, Inbred C57BLMice, KnockoutSeverity of Illness IndexSindbis VirusInterferon-alphaInterferon Regulatory Factor-7Interferon Type IIrf7 protein, mouseCNSInterferonIRF7MonocyteSindbis
Identifiers
PMID42343382
PMCPMC13625333
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