ArticleBMC ophthalmology2026
Hand-eye laterality and structural asymmetry between dominant and non-dominant eyes: a multi-modal study in 524 healthy volunteers.
Article in BMC ophthalmology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundTo investigate the relationship between ocular and hand dominance patterns in healthy volunteers and to evaluate structural differences between dominant and non-dominant eyes using anterior and posterior segment measurements.
methodsThis cross-sectional study included 524 healthy volunteers (50% female, age 20-60). Ocular dominance was determined using the hole-in-card test and hand dominance with the Edinburgh Handedness Inventory. Participants underwent Swept-Source Optical Coherence Tomography for retinal nerve fiber layer (RNFL), ganglion cell complex (GCC), subfoveal choroidal thickness (SFCT), and choroidal vascularity index (CVI) measurements; Scheimpflug imaging for anterior segment parameters; and partial coherence interferometry for axial length determination.
resultsRight eye dominance was observed in 60.9% and left eye dominance in 39.1% of participants. A pronounced cross-lateralization pattern emerged: 93.6% of left eye dominant individuals exhibited right hand dominance, significantly higher than in right eye dominant participants (57.1% right-handed, p = 0.024; 42.9% left-handed, p = 0.016). After correction for multiple comparisons, dominant eyes demonstrated significantly greater central corneal thickness (p = 0.002). RNFL nasal quadrant thickness showed the strongest trend toward significance (p = 0.014). Axial length, additional RNFL quadrants, and GCC sectors demonstrated consistent trends toward significance. No differences were found in SFCT or CVI.
conclusionsDominant eyes demonstrated significantly greater central corneal thickness after correction for multiple comparisons, with nasal RNFL thickness showing the strongest trend toward significance. A differential lateralization pattern was observed between ocular dominance groups, suggesting a potential association between ocular and manual preferences; however, this finding warrants cautious interpretation given the population-level prevalence of right-handedness.
trial registrationThis cross-sectional study was approved by the Institutional Ethics Committee of İzmir Democracy University, Buca Seyfi Demirsoy Training and Research Hospital (date: 26.03.2025; number: 2025/427) and adhered to the principles of the Declaration of Helsinki.
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