Evidence map›Paper›PMID 42343156›Full record

ArticleGut microbes2026

Microbiome-driven alterations in tryptophan metabolism contribute to behavioral comorbidities in the Muc2 knockout mouse model of chronic colitis.

Jessica K Josephson, Jacqueline A Barnett, Emad Yuzbashian, Andrea Verdugo-Meza, Susan J Murch, Tyler J Wenzel, Andis Klegeris, Keith A Sharkey, Deanna L Gibson

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Gut microbes, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jessica K JosephsonDepartment of Biology, University of British Columbia, Kelowna, BC, Canada.ORCID 0000-0003-2216-376X
Jacqueline A BarnettDepartment of Biology, University of British Columbia, Kelowna, BC, Canada.ORCID 0000-0001-6924-3674
Emad YuzbashianDepartment of Biology, University of British Columbia, Kelowna, BC, Canada.
Andrea Verdugo-MezaDepartment of Biology, University of British Columbia, Kelowna, BC, Canada.ORCID 0000-0001-9097-4965
Susan J MurchDepartment of Chemistry, University of British Columbia, Kelowna, BC, Canada.
Tyler J WenzelDepartment of Biology, University of British Columbia, Kelowna, BC, Canada.
Andis KlegerisDepartment of Biology, University of British Columbia, Kelowna, BC, Canada.
Keith A SharkeyDepartment of Physiology and Pharmacology, Hotchkiss Brain Institute and Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.ORCID 0000-0001-9560-1711
Deanna L GibsonDepartment of Biology, University of British Columbia, Kelowna, BC, Canada.ORCID 0000-0003-0052-7550

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Globally, the incidence of inflammatory bowel disease (IBD) is projected to reach 0.5% of the population by 2030, with increasing recognition of neurobehavioral comorbidities, including anxiety, depression, and cognitive dysfunction. The mechanisms underlying these comorbidities remain unclear but may involve interacting pathways, including microbial dysbiosis, inflammation and imbalanced neurometabolite production. Here, we investigated whether microbiome-associated alterations in neurometabolites are correlated with behavioral changes in a chronic colitis model. Specific pathogen-free (SPF) and germ-free (GF) mucin 2 knockout mice (Muc2

Indexed as

ColitisGastrointestinal MicrobiomeMucin-2TryptophanAnimalsAnxietyChronic DiseaseColonDisease Models, AnimalDysbiosisFemaleMaleMiceMice, Inbred C57BLMice, KnockoutMuc2 protein, mouseMucin-2Tryptophancolitisgut–brain–microbiome axisGut microbiome dysbiosiskynurenineserotonintryptophan

Identifiers

PMID42343156
PMCPMC13313184

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.