Evidence map›Paper›PMID 42343149›Full record

ArticleJournal of enzyme inhibition and medicinal chemistry2026

Design, synthesis, and antibacterial activity study of pyrroloquinazoline diamine derivatives.

Muchun Cheng, YaJing Tian, JieYa Shang, Weiqing He, Ying Zheng, Can Yan, Xinyu Chen, Jiawei Li, YuanYing Jiang, Qiang Fu and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of enzyme inhibition and medicinal chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Muchun ChengAffiliated Hospital of Jinggangshan University, Jiangxi Province Key Laboratory of Organ Development and Epigenetics, College of Traditional Chinese Medicine and Pharmacy, Jinggangshan University, Ji'an, Jiangxi, P.R. China.
YaJing TianAffiliated Hospital of Jinggangshan University, Jiangxi Province Key Laboratory of Organ Development and Epigenetics, College of Traditional Chinese Medicine and Pharmacy, Jinggangshan University, Ji'an, Jiangxi, P.R. China.
JieYa ShangAffiliated Hospital of Jinggangshan University, Jiangxi Province Key Laboratory of Organ Development and Epigenetics, College of Traditional Chinese Medicine and Pharmacy, Jinggangshan University, Ji'an, Jiangxi, P.R. China.
Weiqing HeAffiliated Hospital of Jinggangshan University, Jiangxi Province Key Laboratory of Organ Development and Epigenetics, College of Traditional Chinese Medicine and Pharmacy, Jinggangshan University, Ji'an, Jiangxi, P.R. China.
Ying ZhengAffiliated Hospital of Jinggangshan University, Jiangxi Province Key Laboratory of Organ Development and Epigenetics, College of Traditional Chinese Medicine and Pharmacy, Jinggangshan University, Ji'an, Jiangxi, P.R. China.
Can YanAffiliated Hospital of Jinggangshan University, Jiangxi Province Key Laboratory of Organ Development and Epigenetics, College of Traditional Chinese Medicine and Pharmacy, Jinggangshan University, Ji'an, Jiangxi, P.R. China.
Xinyu ChenAffiliated Hospital of Jinggangshan University, Jiangxi Province Key Laboratory of Organ Development and Epigenetics, College of Traditional Chinese Medicine and Pharmacy, Jinggangshan University, Ji'an, Jiangxi, P.R. China.
Jiawei LiAffiliated Hospital of Jinggangshan University, Jiangxi Province Key Laboratory of Organ Development and Epigenetics, College of Traditional Chinese Medicine and Pharmacy, Jinggangshan University, Ji'an, Jiangxi, P.R. China.
YuanYing JiangSchool of Medicine, Tongji University, Shanghai, China.
Qiang FuAffiliated Hospital of Jinggangshan University, Jiangxi Province Key Laboratory of Organ Development and Epigenetics, College of Traditional Chinese Medicine and Pharmacy, Jinggangshan University, Ji'an, Jiangxi, P.R. China.
Xianqing DengAffiliated Hospital of Jinggangshan University, Jiangxi Province Key Laboratory of Organ Development and Epigenetics, College of Traditional Chinese Medicine and Pharmacy, Jinggangshan University, Ji'an, Jiangxi, P.R. China.
Xunli XiaoAffiliated Hospital of Jinggangshan University, Jiangxi Province Key Laboratory of Organ Development and Epigenetics, College of Traditional Chinese Medicine and Pharmacy, Jinggangshan University, Ji'an, Jiangxi, P.R. China.
Mingxia SongAffiliated Hospital of Jinggangshan University, Jiangxi Province Key Laboratory of Organ Development and Epigenetics, College of Traditional Chinese Medicine and Pharmacy, Jinggangshan University, Ji'an, Jiangxi, P.R. China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

To combat antimicrobial resistance (AMR), a novel series of pyrrolo[3,2-

Indexed as

Anti-Bacterial AgentsDiaminesDrug DesignFolic Acid AntagonistsGram-Negative BacteriaGram-Positive BacteriaPyrrolesQuinazolinesDose-Response Relationship, DrugMicrobial Sensitivity TestsMolecular StructureStructure-Activity RelationshipTetrahydrofolate DehydrogenaseAnti-Bacterial AgentsDiaminesFolic Acid AntagonistsPyrrolesQuinazolinesTetrahydrofolate DehydrogenaseAntimicrobial activitycytotoxicityDHFRdockingquinazoline diamine

Identifiers

PMID42343149
PMCPMC13295075

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.