Evidence map›Paper›PMID 42343132›Full record

ArticleNature2026

Epiblast diversification and blood formation in a human pregastrula.

Zhenyu Xiao, Yandong Gong, Xiaolong Yang, Nannan He, Xinyuan Wang, Guoju You, Hanlin Zhu, Yingping Liang, Xinwei Xie, Baoqi Fang and 3 more

Abstract read
PubMed Publisher
In one paragraph

Article in Nature, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Zhenyu Xiao *State Key Laboratory of Experimental Hematology, School of Life Science, Beijing Institute of Technology, Beijing, China. xiaozy@bit.edu.cn.ORCID http://orcid.org/0000-0003-4445-8219
Yandong Gong *State Key Laboratory of Experimental Hematology, Haihe Laboratory of Cell Ecosystem, Senior Department of Hematology, Fifth Medical Center, Medical Innovation Research Department, Chinese PLA General Hospital, Beijing, China.ORCID https://orcid.org/0000-0003-3971-1478
Xiaolong Yang *State Key Laboratory of Experimental Hematology, School of Life Science, Beijing Institute of Technology, Beijing, China.
Nannan He *Department of Gynecology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Xinyuan WangState Key Laboratory of Experimental Hematology, School of Life Science, Beijing Institute of Technology, Beijing, China.
Guoju YouState Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, China.
Hanlin ZhuState Key Laboratory of Experimental Hematology, School of Life Science, Beijing Institute of Technology, Beijing, China.
Yingping LiangState Key Laboratory of Experimental Hematology, School of Life Science, Beijing Institute of Technology, Beijing, China.
Xinwei XieState Key Laboratory of Experimental Hematology, School of Life Science, Beijing Institute of Technology, Beijing, China.
Baoqi FangState Key Laboratory of Experimental Hematology, School of Life Science, Beijing Institute of Technology, Beijing, China.
Gaoke LiuDepartment of Medical Genetics, College of Basic Medical Science, Army Medical University (Third Military Medical University), Chongqing, China.
Bing LiuState Key Laboratory of Experimental Hematology, Haihe Laboratory of Cell Ecosystem, Senior Department of Hematology, Fifth Medical Center, Medical Innovation Research Department, Chinese PLA General Hospital, Beijing, China. bingliu17@126.com.
Yu LanState Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, China. lanyu@ihcams.ac.cn.ORCID http://orcid.org/0000-0002-4731-5945

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The incipient stage of gastrulation in human, when the primitive streak is about to emerge, represents a critical yet underexplored period. Here we present the high-resolution spatial transcriptomic landscape of a human embryo at Carnegie stage 6 (approximately 13-14 days post-conception), a stage at which primitive streak remains invisible and gastrulation-derived mesodermal/endodermal progenitors are not yet transcriptomically detected. We identified an anterior visceral endoderm-like hypoblast population, as well as a trifurcated developmental trajectory of the epiblast, progressing towards the amnion, primitive streak and node/prechordal plate/notochord (axial mesoderm) at subsequent developmental stages

Indexed as

GastrulaGerm LayersHematopoiesisCell LineageEndodermFemaleGastrulationHumansMaleMesodermPrimitive StreakYolk Sac

Identifiers

PMID42343132

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.