Evidence map›Paper›PMID 42343131›Full record

ArticleNature2026

Alternate RNA decoding results in stable and abundant proteins in mammals.

Shira Tsour, Rainer Machné, Andrew Leduc, Simon Widmer, Eunice Koo, Jeremy Guez, Konrad J Karczewski, Nikolai Slavov

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Computing complexity.Nature chemical biology · 2026
    Article
  2. Article
  3. Review
  4. A pan-cancer atlas of therapeutic T cell targets.bioRxiv : the preprint server for biology · 2025
    Article
  5. Impact of protein degradation and cell growth on mammalian proteomes.bioRxiv : the preprint server for biology · 2025
    Article
  6. Review
  7. Assessing Human Ribosomal DNA Variation and Its Association With Phenotypic Outcomes.BioEssays : news and reviews in molecular, cellular and developmental biology · 2025
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Shira TsourDepartments of Bioengineering, Biology, Chemistry and Chemical Biology, Single Cell Proteomics Center, Northeastern University, Boston, MA, USA.ORCID http://orcid.org/0000-0003-1382-4044
Rainer MachnéDepartments of Bioengineering, Biology, Chemistry and Chemical Biology, Single Cell Proteomics Center, Northeastern University, Boston, MA, USA.ORCID http://orcid.org/0000-0002-1274-5099
Andrew LeducDepartments of Bioengineering, Biology, Chemistry and Chemical Biology, Single Cell Proteomics Center, Northeastern University, Boston, MA, USA.
Simon WidmerDepartments of Bioengineering, Biology, Chemistry and Chemical Biology, Single Cell Proteomics Center, Northeastern University, Boston, MA, USA.ORCID http://orcid.org/0000-0003-1335-744X
Eunice KooDepartments of Bioengineering, Biology, Chemistry and Chemical Biology, Single Cell Proteomics Center, Northeastern University, Boston, MA, USA.ORCID http://orcid.org/0009-0003-6965-001X
Jeremy GuezProgram in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID http://orcid.org/0009-0007-6406-5187
Konrad J KarczewskiProgram in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID http://orcid.org/0000-0003-2878-4671
Nikolai SlavovDepartments of Bioengineering, Biology, Chemistry and Chemical Biology, Single Cell Proteomics Center, Northeastern University, Boston, MA, USA. nslavov@northeastern.edu.ORCID http://orcid.org/0000-0003-2035-1820

Funding

Single-cell proteomic identification of novel markers of senescenceUH3CA268117 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI DOU, ZHIXUN, RAJAGOPAL, JAYARAJ · 2023 to 2024
$1.9M
Comprehensive and Cell Type-Specific Proteogenomic Profiling of Aberrant and Mis-Processed Proteins in Alzheimer's Disease and Tauopathy ModelsR01AG092460 · NIA · NORTHEASTERN UNIVERSITY · PI Mahlon Collins, BRADLEY T. HYMAN · 2025 to 2026
$1.5M
Molecular and metabolic influences on the activation of monocytes and macrophages at single-cell resolutionR35GM148218 · NIGMS · NORTHEASTERN UNIVERSITY · PI Nikolai Slavov · 2023 to 2026
$1.5M
Single-cell proteomic identification of novel markers of senescenceUG3CA268117 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI DOU, ZHIXUN, RAJAGOPAL, JAYARAJ · 2021 to 2022
$1.2M
Collaborative Research: DMS/NIGMS 2: Methods for Systematic Analysis of Post-transcriptional Regulation in Single CellsR01GM144967 · NIGMS · UNIVERSITY OF CALIFORNIA SANTA BARBARA · PI FRANKS, ALEXANDER, SLAVOV, NIKOLAI · 2021 to 2024
$779k
NCI NIH HHS UG3 CA268117NCI NIH HHS UH3 CA268117NIA NIH HHS R01 AG092460NIGMS NIH HHS R01 GM144967NIGMS NIH HHS R35 GM148218
6 · The paper itself

Abstract

Amino acid substitutions may substantially alter protein stability and function

Indexed as

Amino Acid SubstitutionGenetic CodeMammalsProtein BiosynthesisProteinsRNAAnimalsCodonHumansNeoplasmsOrgan SpecificityProtein StabilityProteomeProteomicsCodonProteinsProteomeRNA

Identifiers

PMID42343131
PMCPMC13384240

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.