Evidence map›Paper›PMID 42343124›Full record

ArticleNature2026

Small-molecule modulation of β-arrestins.

Alem W Kahsai, Natalia Pakharukova, Henry Y Kwon, Kunal S Shah, Caroline T Del Real, Bowie N Shreiber, Jason G Liang-Lin, Paul J Shim, Mason A Lee, Van A Ngo and 25 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Cardiomyocyte β-arrestins mediate inflammation and cGAS-STING activation in CVB3 viral myocarditis.American journal of physiology. Heart and circulatory physiology · 2026
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

35 authors.

Alem W Kahsai *Department of Medicine, Duke University Medical Center, Durham, NC, USA. alem@receptor-biol.duke.edu.ORCID http://orcid.org/0000-0001-9272-4484
Natalia Pakharukova *Department of Medicine, Duke University Medical Center, Durham, NC, USA.
Henry Y KwonDepartment of Medicine, Duke University Medical Center, Durham, NC, USA.ORCID http://orcid.org/0000-0001-7031-9023
Kunal S ShahDepartment of Medicine, Duke University Medical Center, Durham, NC, USA.ORCID http://orcid.org/0000-0001-9906-3025
Caroline T Del RealDepartment of Medicine, Duke University Medical Center, Durham, NC, USA.ORCID http://orcid.org/0009-0002-7466-4435
Bowie N ShreiberDepartment of Medicine, Duke University Medical Center, Durham, NC, USA.ORCID http://orcid.org/0000-0003-3134-4431
Jason G Liang-LinDepartment of Medicine, Duke University Medical Center, Durham, NC, USA.ORCID http://orcid.org/0000-0003-4277-6694
Paul J ShimDepartment of Medicine, Duke University Medical Center, Durham, NC, USA.ORCID http://orcid.org/0000-0002-6610-8378
Mason A LeeDepartment of Medicine, Duke University Medical Center, Durham, NC, USA.ORCID http://orcid.org/0000-0001-8772-3567
Van A NgoUS Department of Energy, National Center for Computational Sciences, Oak Ridge National Laboratory, Oak Ridge, TN, USA.ORCID http://orcid.org/0000-0001-8350-1203
Allison M SchwalbDepartment of Medicine, Duke University Medical Center, Durham, NC, USA.
Uyen PhamDepartment of Medicine, Duke University Medical Center, Durham, NC, USA.ORCID http://orcid.org/0000-0002-2038-6794
Anand ChundiDepartment of Medicine, Duke University Medical Center, Durham, NC, USA.ORCID http://orcid.org/0000-0001-8148-7479
Haoran JiangDepartment of Medicine, Duke University Medical Center, Durham, NC, USA.ORCID http://orcid.org/0000-0001-5916-3072
Emmanuel Flores-EspinozaDepartment of Molecular Pathobiology, New York University College of Dentistry, New York, NY, USA.ORCID http://orcid.org/0000-0002-7889-7458
Samuel LiuDepartment of Medicine, Duke University Medical Center, Durham, NC, USA.
Preston C NibleyDepartment of Medicine, Duke University Medical Center, Durham, NC, USA.
Dana K BassfordDepartment of Medicine, Duke University Medical Center, Durham, NC, USA.
Hyunggu HahnDepartment of Molecular Pathobiology, New York University College of Dentistry, New York, NY, USA.ORCID http://orcid.org/0000-0003-3532-7671
Cal A KunzleDepartment of Medicine, Duke University Medical Center, Durham, NC, USA.
Brittany N ThomasDepartment of Medicine, Duke University Medical Center, Durham, NC, USA.ORCID http://orcid.org/0000-0001-8317-7538
Jihee KimDepartment of Medicine, Duke University Medical Center, Durham, NC, USA.
Yang ZhouDepartment of Cell Biology, Duke University Medical Center, Durham, NC, USA.
Jialu WangDepartment of Medicine, Duke University Medical Center, Durham, NC, USA.
Xingdong ZhangDepartment of Medicine, Duke University Medical Center, Durham, NC, USA.
Jeffrey S SmithDepartment of Medicine, Duke University Medical Center, Durham, NC, USA.
Lindsay A M ReinDepartment of Medicine, Duke University Medical Center, Durham, NC, USA.
Alex R B ThomsenDepartment of Molecular Pathobiology, New York University College of Dentistry, New York, NY, USA.ORCID http://orcid.org/0000-0003-1638-8911
Sudha K ShenoyDepartment of Medicine, Duke University Medical Center, Durham, NC, USA.ORCID http://orcid.org/0000-0002-2565-4663
Sudarshan RajagopalDepartment of Medicine, Duke University Medical Center, Durham, NC, USA.ORCID http://orcid.org/0000-0002-3443-5040
Lei ShiComputational Chemistry and Molecular Biophysics Section, National Institute on Drug Abuse-Intramural Research Program, National Institutes of Health, Baltimore, MD, USA.ORCID http://orcid.org/0000-0002-4137-096X
Seungkirl AhnDepartment of Medicine, Duke University Medical Center, Durham, NC, USA.ORCID http://orcid.org/0000-0001-5681-3789
Howard A RockmanDepartment of Medicine, Duke University Medical Center, Durham, NC, USA.ORCID http://orcid.org/0000-0003-2921-1584
Ali MasoudiDepartment of Medicine, Duke University Medical Center, Durham, NC, USA.
Robert J LefkowitzDepartment of Medicine, Duke University Medical Center, Durham, NC, USA. lefko001@receptor-biol.duke.edu.ORCID http://orcid.org/0000-0003-1472-7545

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

β-Arrestins are multifunctional regulators of G-protein-coupled receptor (GPCR) signalling and orchestrate diverse downstream signalling events and physiological responses across the GPCR superfamily

Indexed as

beta-ArrestinsSmall Molecule LibrariesAnimalsBinding SitesCryoelectron MicroscopyHumansModels, MolecularMolecular Dynamics SimulationProtein ConformationReceptors, G-Protein-Coupledbeta-ArrestinsReceptors, G-Protein-CoupledSmall Molecule Libraries

Identifiers

PMID42343124
PMCPMC13489962

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.