Evidence map›Paper›PMID 42342999›Full record

ArticleMolecular neurobiology2026

Influence of Ketogenic Diet Lipid Composition on Anxiety-Like Behavior and Neurometabolic Profile in Healthy Rats.

Glaucivan Gomes Gurgel, Júlia Galbiati de Souza, Ribanna Aparecida Marques Braga, Fernanda Marques Rodrigues, Andrea Matheus Faccioli, Maria Eduarda Gonçalves Fortes, Eduardo Alves da Silva, Rosana Aparecida Manólio Soares Freitas, Ricardo Mario Arida, Carla Alessandra Scorza and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular neurobiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Glaucivan Gomes GurgelDepartment of Nutrition, School of Public Health, University of São Paulo, Av. Dr. Arnaldo, 715; CEP, São Paulo, SP, 01246-904, Brazil.ORCID http://orcid.org/0000-0003-2252-7789
Júlia Galbiati de SouzaDepartment of Nutrition, School of Public Health, University of São Paulo, Av. Dr. Arnaldo, 715; CEP, São Paulo, SP, 01246-904, Brazil.ORCID http://orcid.org/0000-0003-1096-1027
Ribanna Aparecida Marques BragaPost-Graduation in Cardiology, Faculty of Medicine, University of São Paulo, São Paulo, Brazil.ORCID http://orcid.org/0000-0003-2122-5658
Fernanda Marques RodriguesDepartment of Nutrition, School of Public Health, University of São Paulo, Av. Dr. Arnaldo, 715; CEP, São Paulo, SP, 01246-904, Brazil.ORCID http://orcid.org/0000-0002-2770-8864
Andrea Matheus FaccioliDepartment of Nutrition, School of Public Health, University of São Paulo, Av. Dr. Arnaldo, 715; CEP, São Paulo, SP, 01246-904, Brazil.ORCID http://orcid.org/0000-0002-7725-8259
Maria Eduarda Gonçalves FortesDepartment of Nutrition, School of Public Health, University of São Paulo, Av. Dr. Arnaldo, 715; CEP, São Paulo, SP, 01246-904, Brazil.ORCID http://orcid.org/0000-0002-5140-6161
Eduardo Alves da SilvaDepartment of Physiology, Federal University of São Paulo, São Paulo, Brazil.ORCID http://orcid.org/0000-0002-4178-4097
Rosana Aparecida Manólio Soares FreitasDepartment of Nutrition, School of Public Health, University of São Paulo, Av. Dr. Arnaldo, 715; CEP, São Paulo, SP, 01246-904, Brazil.ORCID http://orcid.org/0000-0001-7955-656X
Ricardo Mario AridaDepartment of Physiology, Federal University of São Paulo, São Paulo, Brazil.ORCID http://orcid.org/0000-0002-7771-6133
Carla Alessandra ScorzaDiscipline of Neuroscience, Department of Neurology and Neurosurgery, Paulista Medical School, Federal University of São Paulo, São Paulo, SP, Brazil.ORCID http://orcid.org/0000-0001-7810-4748
Emerson Soares BernardesInstituto de Pesquisas Energéticas E Nucleares, IPEN, CNEN/SP, São Paulo, SP, Brazil.ORCID http://orcid.org/0000-0002-0029-7313
Sofia Nascimento Dos SantosSchool of Biomedical Engineering and Imaging Sciences, King's College London, London, UK.ORCID http://orcid.org/0000-0001-8795-316X
Nágila Raquel Teixeira DamascenoDepartment of Nutrition, School of Public Health, University of São Paulo, Av. Dr. Arnaldo, 715; CEP, São Paulo, SP, 01246-904, Brazil. nagila@usp.br.ORCID http://orcid.org/0000-0002-9332-7816

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico 130473/2020-0 and 309480/2021-3Coordenação de Aperfeiçoamento de Pessoal de Nível Superior 88887.609440/2021-00Coordenação de Aperfeiçoamento de Pessoal de Nível Superior 88887.646449/2021-00 and 88887.659109/2021-00Fundação de Amparo à Pesquisa do Estado de São Paulo 2020/03529-6Fundação de Amparo à Pesquisa do Estado de São Paulo 2020/08837-0Fundação de Amparo à Pesquisa do Estado de São Paulo 2020/13508-8Fundação de Amparo à Pesquisa do Estado de São Paulo 2022/03738-0Fundação de Amparo à Pesquisa do Estado de São Paulo 2022/09893-7Instituto Nacional de Ciência e Tecnologia de Fluidos Complexos 2014/50983-3
6 · The paper itself

Abstract

Ketogenic diets (KDs) modulate brain function, but how their fatty acid composition impacts behavior remains poorly understood. Male Wistar rats were fed a control diet (CD, n = 6), a classic ketogenic diet (CKD, n = 6) rich in saturated fatty acids (SAFAs), or a modified ketogenic diet (MKD, n = 6) enriched with polyunsaturated fatty acids (PUFAs) and DHA. After 100 days, both KDs induced similar ketosis and increased brain glucose metabolism (

Indexed as

AnxietyBehavior, AnimalDiet, KetogenicLipidsAnimalsBrainFatty AcidsGlucoseKetosisMaleRatsRats, WistarFatty AcidsGlucoseLipidsAnxiety-like behaviorDocosahexaenoic acidFatty acid compositionHippocampusKetogenic dietNeuroinflammation

Identifiers

PMID42342999
PMCPMC13294337

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.