Evidence map›Paper›PMID 42342864›Full record

ReviewInternational orthopaedics2026

Reluctant knee: understanding and managing stiffness after total knee arthroplasty.

Sakeena Hosanee, Nnena Elebo, Nkhodiseni Sikhauli, Jurek Rafal Tomasz Pietrzak

Abstract readReview
In one paragraph

Review in International orthopaedics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Sakeena HosaneeDivision of Orthopaedics, University of the Witwatersrand, Johannesburg, South Africa. sakeenahosanee@gmail.com.
Nnena EleboDivision of Orthopaedics, University of the Witwatersrand, Johannesburg, South Africa.
Nkhodiseni SikhauliDivision of Orthopaedics, University of the Witwatersrand, Johannesburg, South Africa.
Jurek Rafal Tomasz PietrzakDivision of Orthopaedics, University of the Witwatersrand, Johannesburg, South Africa. jrtpietrzak@yahoo.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposePost-total knee arthroplasty (TKA) stiffness remains a clinically important cause of pain, restricted range of motion (ROM), functional limitation, and reintervention. This narrative review synthesises current evidence on the pathophysiology, evaluation, and staged management of post-TKA stiffness, with particular emphasis on manipulation under anaesthesia (MUA).

methodsA narrative review was performed using literature relating to post-TKA stiffness, arthrofibrosis, diagnostic evaluation, rehabilitation, MUA, lysis of adhesions, and revision TKA. Evidence was synthesised thematically to support a practical diagnostic and management framework.

resultsAcquired idiopathic stiffness occurs in approximately 3.6% to 4.0% of TKAs, while MUA is required in roughly 2.6% to 3.6% of cases. The available literature supports a diagnosis-of-exclusion approach, in which infection, component malposition, instability, and other secondary causes are excluded before arthrofibrosis is diagnosed. MUA remains the principal first-line procedural intervention once early conservative measures fail. Earlier MUA, generally within 6-12 weeks, is associated with greater ROM gain than delayed intervention, although outcomes remain influenced by baseline ROM severity, patient selection, and the quality of post-manipulation rehabilitation.

conclusionPost-TKA stiffness is a heterogeneous complication requiring structured evaluation and staged management. When MUA fails, escalation to arthrolysis or revision TKA should be individualised and guided by the distinction between persistent soft-tissue fibrosis and correctable mechanical pathology. A practical algorithm is proposed to support diagnosis, timing of intervention, and escalation after failed MUA.

Indexed as

Arthroplasty, Replacement, KneeKnee JointPostoperative ComplicationsFibrosisHumansRange of Motion, ArticularReoperationArthrofibrosisManipulation under anaesthesiaPostoperative knee stiffnessRange of motion limitationTotal knee arthroplasty

Identifiers

PMID42342864
PMCPMC13562152

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.