Evidence map›Paper›PMID 42342847›Full record

ArticleCommunications biology2026

TPH1-dependent maternal hyposerotonemia: long-term effects on adult wild-type mouse offspring.

Françoise Saurini, Carolina Jaliffa, Gwenaëlle Le Pen, Zsolt Csaba, Chantal Joubert, Jacques Callebert, Jean-Marie Launay, Catherine Senamaud-Beaufort, Oumy Seydi, Pierre Gressens and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Communications biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Françoise SauriniUniversité Paris Cité, Inserm U1141, NeuroDiderot, Paris, France.
Carolina JaliffaInstitute of Pathology, Kantonsspital Baden AG, Baden, Switzerland.
Gwenaëlle Le PenUniversité Paris Cité, Institute of Psychiatry and Neuroscience of Paris (IPNP), Inserm U1266, Team Physiopathology of Psychiatric Disorders, Paris, France.
Zsolt CsabaUniversité Paris Cité, Inserm U1141, NeuroDiderot, Paris, France.
Chantal JoubertUniversité Paris Cité, Inserm U1141, NeuroDiderot, Paris, France.
Jacques CallebertLaboratoire de Biochimie et Biologie Moléculaire, Hôpital Lariboisière, AP-HP, Paris, France.
Jean-Marie LaunayLaboratoire de Biochimie et Biologie Moléculaire, Hôpital Lariboisière, AP-HP, Paris, France.
Catherine Senamaud-BeaufortGenomiqueENS, Institut de Biologie de l'ENS, Département de biologie, École normale supérieure, CNRS, Inserm, Université PSL, Paris, France.ORCID http://orcid.org/0000-0001-7074-0416
Oumy SeydiGenomiqueENS, Institut de Biologie de l'ENS, Département de biologie, École normale supérieure, CNRS, Inserm, Université PSL, Paris, France.
Pierre GressensUniversité Paris Cité, Inserm U1141, NeuroDiderot, Paris, France.ORCID http://orcid.org/0000-0002-0909-4221
Guilan VodjdaniUniversité Paris Cité, Inserm U1141, NeuroDiderot, Paris, France.
Sylvie BerrardUniversité Paris Cité, Inserm U1141, NeuroDiderot, Paris, France.
Tania VitalisUniversité Paris Cité, Inserm U1141, NeuroDiderot, Paris, France. tnvitalis@gmail.com.ORCID http://orcid.org/0000-0002-5531-3771

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Numerous mood and behavior disorders have developmental origins resulting from genetic and environmental interactions. Maternal tryptophan hydroxylase 1 (TPH-1)-dependent serotonin (5-HT) depletion alters embryonic brain development, but its long-term impact on adult progeny has never been investigated. Here we demonstrate that adult WT male offspring born to hyposerotonergic Tph1

Indexed as

Prenatal Exposure Delayed EffectsSerotoninTryptophan HydroxylaseAnimalsBrainDevelopmental Origins of Health and DiseaseDopamineFemaleMaleMiceNorepinephrinePregnancyDopamineNorepinephrineSerotoninTph1 protein, mouseTryptophan Hydroxylase

Identifiers

PMID42342847
PMCPMC13658211

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.