Evidence map›Paper›PMID 42342716›Full record

ArticleNature communications2026

Neutrophil-derived S100A8/A9 impairs megakaryocyte maturation in immune thrombocytopenia.

Jiaqian Qi, Meng Zhou, Jie Yin, Xiaofei Song, Yan Zhang, Haohao Han, Xueqian Li, Ziyan Zhang, Yaqiong Tang, Fei Yang and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Jiaqian Qi *National Clinical Research Center for Hematologic Diseases, Jiangsu Institute of Hematology, The First Affiliated Hospital of Soochow University, Suzhou, China.
Meng Zhou *National Clinical Research Center for Hematologic Diseases, Jiangsu Institute of Hematology, The First Affiliated Hospital of Soochow University, Suzhou, China.
Jie Yin *National Clinical Research Center for Hematologic Diseases, Jiangsu Institute of Hematology, The First Affiliated Hospital of Soochow University, Suzhou, China.
Xiaofei Song *National Clinical Research Center for Hematologic Diseases, Jiangsu Institute of Hematology, The First Affiliated Hospital of Soochow University, Suzhou, China.
Yan Zhang *Saha Cardiovascular Research Center, College of Medicine, University of Kentucky, Lexington, KY, USA.
Haohao HanNational Clinical Research Center for Hematologic Diseases, Jiangsu Institute of Hematology, The First Affiliated Hospital of Soochow University, Suzhou, China.
Xueqian LiNational Clinical Research Center for Hematologic Diseases, Jiangsu Institute of Hematology, The First Affiliated Hospital of Soochow University, Suzhou, China.
Ziyan ZhangNational Clinical Research Center for Hematologic Diseases, Jiangsu Institute of Hematology, The First Affiliated Hospital of Soochow University, Suzhou, China.ORCID http://orcid.org/0000-0002-2001-2354
Yaqiong TangNational Clinical Research Center for Hematologic Diseases, Jiangsu Institute of Hematology, The First Affiliated Hospital of Soochow University, Suzhou, China.
Fei YangNational Clinical Research Center for Hematologic Diseases, Jiangsu Institute of Hematology, The First Affiliated Hospital of Soochow University, Suzhou, China.
Depei WuNational Clinical Research Center for Hematologic Diseases, Jiangsu Institute of Hematology, The First Affiliated Hospital of Soochow University, Suzhou, China. drwudepei@163.com.ORCID http://orcid.org/0000-0002-6312-3863
Zhenyu LiSaha Cardiovascular Research Center, College of Medicine, University of Kentucky, Lexington, KY, USA. zli.tamu21@gmail.com.
Yue HanNational Clinical Research Center for Hematologic Diseases, Jiangsu Institute of Hematology, The First Affiliated Hospital of Soochow University, Suzhou, China. hanyue@suda.edu.cn.ORCID http://orcid.org/0000-0002-7560-7195

Funding

National Natural Science Foundation of China (National Science Foundation of China) 82200133National Natural Science Foundation of China (National Science Foundation of China) 82230005
6 · The paper itself

Abstract

Immune thrombocytopenia (ITP) features autoantibody-mediated platelet clearance, but how inflammatory mediators impair thrombopoiesis remains less defined. Using single-cell and spatial transcriptomics, we identify a neutrophil-megakaryocyte axis in ITP marrow in which neutrophil-derived S100A8/A9 engages TLR4 and activates JNK/c-Jun signaling. This pathway represses the megakaryocyte master regulator GATA1 and constrains maturation. In primary CD34

Indexed as

Calgranulin ACalgranulin BMegakaryocytesNeutrophilsPurpura, Thrombocytopenic, IdiopathicAnimalsBlood PlateletsDisease Models, AnimalFemaleGATA1 Transcription FactorHumansMaleMiceMice, Inbred C57BLSignal TransductionThrombopoiesisCalgranulin ACalgranulin BGATA1 Transcription FactorS100a8 protein, mouseS100A9 protein, humanS100A9 protein, mouseTlr4 protein, mouseToll-Like Receptor 4

Identifiers

PMID42342716
PMCPMC13448809

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.