Evidence map›Paper›PMID 42342712›Full record

ArticleNPJ vaccines2026

BCG enables protection against malaria through adjuvanting an adenovirus-vectored vaccine.

Sören Reinke, Marta Ulaszewska, Qi Su, Lee Sims, Romain Guyon, Adam Truby, Gundra Raissar, Jelena S Bezbradica, Joannah R Fergusson, Anita Milicic

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NPJ vaccines, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Sören ReinkeThe Jenner Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
Marta UlaszewskaThe Jenner Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
Qi SuKennedy Institute of Rheumatology Research, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, Medical Sciences Division, University of Oxford, Oxford, UK.
Lee SimsThe Jenner Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
Romain GuyonThe Jenner Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
Adam TrubyThe Jenner Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
Gundra RaissarThe Jenner Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
Jelena S BezbradicaKennedy Institute of Rheumatology Research, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, Medical Sciences Division, University of Oxford, Oxford, UK.
Joannah R FergussonKennedy Institute of Rheumatology Research, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, Medical Sciences Division, University of Oxford, Oxford, UK.
Anita MilicicThe Jenner Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK. anita.milicic@ndm.ox.ac.uk.

Funding

cGMP Manufacture, Fill-Finish, Release, Analytical and Stability Testing and Stability Program of a Nanoparticle Based HIV Envelope Vaccine75N93022D00005 · NIAID · INTERNATIONAL AIDS VACCINE INITIATIVE · PI HASSELL, THOMAS · 2022 to 2025
$8.0M
Task Area A shall encompass annual follow-up of cohort members, clinical events investigations, study operations, and data analysis and manuscript writing. If implemented, Task A.1 will provide fundin75N92020D00005 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI WATSON, KAROL E · 2020 to 2025
$5.1M
Chan Zuckerberg Initiative 2020-217289Deutsche Forschungsgemeinschaft 495054088Engineering and Physical Sciences Research Council VaxHub GlobalKennedy Trust for Rheumatology Research KENN212202Medical Research Council MC_PC_16056Medical Research Council MR/Y004450/1MRC UK MR/W001217/1NHLBI NIH HHS 75N92020D00005NIAID NIH HHS 75N93022D00005NIDA NIH HHS 75N95020D00005NIH HHS 75N93023D00005NIH HHS 75N99020D00005
6 · The paper itself

Abstract

BCG vaccination against TB may also reduce malaria incidence through non-specific innate immune activation. We investigated whether giving BCG alongside an adenoviral-vectored malaria vaccine improves protection against malaria in mice. Co-immunisation broadened and strengthened the early innate cytokine responses, enabling strong CD8

Identifiers

PMID42342712
PMCPMC13654936

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.