Evidence map›Paper›PMID 42342702›Full record

ArticleScientific reports2026

Design, synthesis, biological evaluation, and in silico characterization of chalcone derivatives as antidiabetic hits.

Arif Ali, Frederico de Bastos Oliveira Dias, Gabriela Ramos Borges, Zubair Hussain, Amir Zada, Gustavo S S Felizardo, Tiago Elias Allievi Frizon, Fethi Ahmet Ozdemir, Ahmet Çetin, Mohammad Naeem and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Arif Ali *Department of Chemistry, Abdul Wali Khan University, Mardan, 23200, Khyber Pakhtunkhwa, Pakistan.
Frederico de Bastos Oliveira Dias *Laboratory of Sustainable Synthesis and Organochalcogen (LabSO), Instituto de Química (IQ), Universidade Federal de Goiás - UFG, Goiânia, GO, 74690-900, Brazil.
Gabriela Ramos BorgesInstituto de Química (INQUI), Universidade Federal Do Mato Grosso Do Sul - UFMS, Campo Grande, MS, 79074-460, Brazil.
Zubair HussainNational Institute for Biotechnology and Genetic Engineering College, Pakistan Institute of Engineering and Applied Sciences, Faisalabad, 44000, Pakistan.
Amir ZadaDepartment of Chemistry, Abdul Wali Khan University, Mardan, 23200, Khyber Pakhtunkhwa, Pakistan.
Gustavo S S FelizardoLaboratory of Cheminformatics (LCi), Faculdade de Farmácia, Universidade Federal de Goiás - UFG, 74605-170, Goiânia, GO, Brazil.
Tiago Elias Allievi FrizonDepartment of Chemistry, Universidade Federal de Santa Catarina, Florianópolis, Santa Catarina, 88040-900, Brazil.
Fethi Ahmet OzdemirFaculty of Science and Art, Bingöl University, Bingöl, 1200, Türkiye.
Ahmet ÇetinFaculty of Science and Art, Bingöl University, Bingöl, 1200, Türkiye.
Mohammad NaeemDepartment of Chemistry, Abdul Wali Khan University, Mardan, 23200, Khyber Pakhtunkhwa, Pakistan.
Luiz Henrique Keng Queiroz JúniorLaboratory of Sustainable Synthesis and Organochalcogen (LabSO), Instituto de Química (IQ), Universidade Federal de Goiás - UFG, Goiânia, GO, 74690-900, Brazil.
Bruno Junior NevesLaboratory of Cheminformatics (LCi), Faculdade de Farmácia, Universidade Federal de Goiás - UFG, 74605-170, Goiânia, GO, Brazil.
Muhammad Ishaq Ali ShahDepartment of Chemistry, Abdul Wali Khan University, Mardan, 23200, Khyber Pakhtunkhwa, Pakistan. ishaqalishah@awkum.edu.pk.
Jamal RafiqueLaboratory of Sustainable Synthesis and Organochalcogen (LabSO), Instituto de Química (IQ), Universidade Federal de Goiás - UFG, Goiânia, GO, 74690-900, Brazil. jamal.rafique@ufms.br.
Sumbal SabaLaboratory of Sustainable Synthesis and Organochalcogen (LabSO), Instituto de Química (IQ), Universidade Federal de Goiás - UFG, Goiânia, GO, 74690-900, Brazil. sumbalsaba@ufg.br.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A series of 40 chalcone derivatives was synthesized through Claisen-Schmidt condensation and characterized by FT-IR and NMR spectroscopy. The compounds were evaluated for α-amylase inhibitory and DPPH radical-scavenging activities to identify chalcone-based hits with a dual in vitro profile relevant to postprandial glycemic control. The series displayed a broad range of activities, with α-amylase IC

Indexed as

ChalconeChalconesDrug DesignHypoglycemic Agentsalpha-AmylasesComputer SimulationEnzyme InhibitorsFree Radical ScavengersHumansMolecular Docking SimulationStructure-Activity Relationshipalpha-AmylasesChalconeChalconesEnzyme InhibitorsFree Radical ScavengersHypoglycemic AgentsChalconesFree radical scavengersMolecular dockingStructure–activity relationshipα-Amylase inhibitors

Identifiers

PMID42342702
PMCPMC13470490

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.