Evidence map›Paper›PMID 42342694›Full record

ArticleNPJ Parkinson's disease2026

Loss of PINK1 causes age-dependent mitochondrial trafficking deficits in nigrostriatal dopaminergic neurons via aberrant p38 MAPK activation.

Jingyu Zhao, Yuanxin Chen, Lianteng Zhi, Qing Xu, Juan Subiry, Zebang Chen, Shiquan Cui, Hui Zhang, Chenjian Li

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NPJ Parkinson's disease, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. [DOT1L controls neuronal amyloid precursor protein expres-sion via the p38 MAPK-mediated mitochondrial dynamics homeostasis axis].Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences · 2026
    Article
  2. Translational Geroscience Strategies for Delaying Multimorbidity.ACS pharmacology & translational science · 2026
    Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jingyu ZhaoThe MOE Key Laboratory of Cell Proliferation and Differentiation, School of Life Sciences, Peking University, Beijing, China.
Yuanxin ChenDepartment of Neuroscience, Thomas Jefferson University, Philadelphia, PA, USA.
Lianteng ZhiDepartment of Neuroscience, Thomas Jefferson University, Philadelphia, PA, USA.
Qing XuBiological and Environmental Sciences and Engineering Division, King Abdullah University of Science and Technology, Thuwal, Saudi Arabia.
Juan SubiryIsakson Center for Neurological Disease Research, Department of Physiology & Pharmacology, College of Veterinary Medicine, The University of Georgia, Athens, GA, USA.
Zebang ChenIsakson Center for Neurological Disease Research, Department of Physiology & Pharmacology, College of Veterinary Medicine, The University of Georgia, Athens, GA, USA.
Shiquan CuiIsakson Center for Neurological Disease Research, Department of Physiology & Pharmacology, College of Veterinary Medicine, The University of Georgia, Athens, GA, USA.
Hui ZhangDepartment of Neuroscience, Thomas Jefferson University, Philadelphia, PA, USA. Hui.Zhang1@UGA.edu.
Chenjian LiThe MOE Key Laboratory of Cell Proliferation and Differentiation, School of Life Sciences, Peking University, Beijing, China. Li_chenjian@pku.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mutations in PTEN-induced putative kinase 1 (PINK1) cause early-onset, autosomal-recessive Parkinson's disease (PD). While previous studies have shown age-related declines in dopamine release and ATP levels in Pink1

Identifiers

PMID42342694
PMCPMC13655179

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.