Evidence map›Paper›PMID 42342690›Full record

ArticleNature communications2026

Parallel cholinergic circuit in oculomotor nucleus to control eye movements and REM sleep.

Chengyong Jiang, Yuanyuan Luo, Xinrong Tan, Hongtao Wang, Qingshuo Meng, Yanyu Xiong, Er Chen, Yuqing Chen, Liyuan Cui, Zhili Huang and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Chengyong Jiang *Institutes of Brain Science, State Key Laboratory of Brain Function and Disorders, MOE Frontiers Center for Brain Science, Fudan University, Shanghai, PR China.
Yuanyuan Luo *Institutes of Brain Science, State Key Laboratory of Brain Function and Disorders, MOE Frontiers Center for Brain Science, Fudan University, Shanghai, PR China.
Xinrong Tan *Institutes of Brain Science, State Key Laboratory of Brain Function and Disorders, MOE Frontiers Center for Brain Science, Fudan University, Shanghai, PR China.
Hongtao WangInstitutes of Brain Science, State Key Laboratory of Brain Function and Disorders, MOE Frontiers Center for Brain Science, Fudan University, Shanghai, PR China.
Qingshuo MengInstitutes of Brain Science, State Key Laboratory of Brain Function and Disorders, MOE Frontiers Center for Brain Science, Fudan University, Shanghai, PR China.
Yanyu XiongInstitutes of Brain Science, State Key Laboratory of Brain Function and Disorders, MOE Frontiers Center for Brain Science, Fudan University, Shanghai, PR China.
Er ChenInstitutes of Brain Science, State Key Laboratory of Brain Function and Disorders, MOE Frontiers Center for Brain Science, Fudan University, Shanghai, PR China.
Yuqing ChenInstitutes of Brain Science, State Key Laboratory of Brain Function and Disorders, MOE Frontiers Center for Brain Science, Fudan University, Shanghai, PR China.
Liyuan CuiInstitutes of Brain Science, State Key Laboratory of Brain Function and Disorders, MOE Frontiers Center for Brain Science, Fudan University, Shanghai, PR China.
Zhili HuangInstitutes of Brain Science, State Key Laboratory of Brain Function and Disorders, MOE Frontiers Center for Brain Science, Fudan University, Shanghai, PR China.ORCID http://orcid.org/0000-0001-9359-1150
Biao YanInstitutes of Brain Science, State Key Laboratory of Brain Function and Disorders, MOE Frontiers Center for Brain Science, Fudan University, Shanghai, PR China. biaoyan@fudan.edu.cn.ORCID http://orcid.org/0000-0003-3252-2965
Jiayi ZhangInstitutes of Brain Science, State Key Laboratory of Brain Function and Disorders, MOE Frontiers Center for Brain Science, Fudan University, Shanghai, PR China. jiayizhang@fudan.edu.cn.ORCID http://orcid.org/0000-0002-1575-0723

Funding

National Natural Science Foundation of China (National Science Foundation of China) T2325008, 82021002, 82588301
6 · The paper itself

Abstract

Sleep suppresses most motor output, yet rapid eye movement sleep (REMs) is marked by brief muscle twitches, including eye movements (EMs), indicating selective motor preservation. How these opposing features are coordinated remains unclear. Here we show that cholinergic neurons in the oculomotor nucleus (nIII

Indexed as

Cholinergic NeuronsEye MovementsOculomotor Nuclear ComplexSleep, REMAnimalsFemaleMaleMiceMice, Inbred C57BLMice, TransgenicOculomotor MusclesOptogeneticsPeriaqueductal GrayVesicular Glutamate Transport Protein 2Vesicular Inhibitory Amino Acid Transport ProteinsWakefulnessSlc17a6 protein, mouseVesicular Glutamate Transport Protein 2Vesicular Inhibitory Amino Acid Transport Proteins

Identifiers

PMID42342690
PMCPMC13448821

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.