ArticleSignal transduction and targeted therapy2026
TCR-mimic bispecific nanobody-based T cell engager targeting intracellular tumor antigens for cancer immunotherapy.
Article in Signal transduction and targeted therapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
T cell engager (TCE) immunotherapies have revolutionized the landscape of cancer treatment; however, their efficacy remains limited by the inaccessibility of intracellular tumor antigens. Conventional bispecific T cell engagers, typically constructed from aggregation-prone single-chain variable fragments (scFvs), suffer from structural instability and an antigenic scope restricted to extracellular targets. To overcome these critical limitations, we presented a proof-of-concept study establishing a modular bispecific VHH‑VHH immunotherapeutic platform. Specifically, we developed a first-in-class TCR-mimic bispecific nanobody (Nb)-based T cell engager (TCRm Bi-NbTE) platform that simultaneously engages CD3ε on T cells and tumor-specific peptide-MHC class I (pMHC I) complexes, exemplified by HLA-A2/WT1
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