Evidence map›Paper›PMID 42342657›Full record

ArticleNature communications2026

hexABC seeking the physical code of DNA.

Federica Battistini, Miłosz Wieczór, Adam Hospital, Marco Pasi, Juan Pablo Arcón, Israel Serrano-Chacón, Alba Sala, Subhamoy Deb, Agustín García-Doñate, Matthew Burman and 24 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

34 authors.

Federica BattistiniInstitute for Research in Biomedicine (IRB Barcelona), Baldiri Reixac 10, Barcelona, Spain.ORCID http://orcid.org/0000-0002-7544-0938
Miłosz Wieczór *Institute for Research in Biomedicine (IRB Barcelona), Baldiri Reixac 10, Barcelona, Spain.ORCID http://orcid.org/0000-0003-4990-8629
Adam Hospital *Institute for Research in Biomedicine (IRB Barcelona), Baldiri Reixac 10, Barcelona, Spain.ORCID http://orcid.org/0000-0002-8291-8071
Marco Pasi *LBPA, UMR8113 CNRS, ENS Paris-Saclay, Universite ́ Paris-Saclay, Gif-sur-Yvette, France.ORCID http://orcid.org/0000-0001-9804-7322
Juan Pablo ArcónInstitute for Research in Biomedicine (IRB Barcelona), Baldiri Reixac 10, Barcelona, Spain.ORCID http://orcid.org/0000-0003-3350-1576
Israel Serrano-ChacónInstitute for Research in Biomedicine (IRB Barcelona), Baldiri Reixac 10, Barcelona, Spain.
Alba SalaInstitute for Research in Biomedicine (IRB Barcelona), Baldiri Reixac 10, Barcelona, Spain.ORCID http://orcid.org/0000-0003-1046-7432
Subhamoy DebInstitute for Research in Biomedicine (IRB Barcelona), Baldiri Reixac 10, Barcelona, Spain.
Agustín García-DoñateInstitute for Research in Biomedicine (IRB Barcelona), Baldiri Reixac 10, Barcelona, Spain.ORCID http://orcid.org/0009-0002-2159-965X
Matthew BurmanSchool of Physics, Engineering and Technology, University of York, York, UK.
Elliot W ChanSchool of Physics, Engineering and Technology, University of York, York, UK.
Liwei ChangDepartment of Chemistry and Quantum Theory Project, University of Florida, Gainesville, FL, USA.ORCID http://orcid.org/0000-0001-5847-0820
Gabriela da RosaDepartment of Biological Sciences, CENUR Litoral Norte, Universidad de la República, Salto, Uruguay.
Jorge R EspinosaYusuf Hamied Department of Chemistry, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0001-9530-2658
Gia Linh HoangComputational Biomedicine, Institute for Neuroscience and Medicine INM-9, Forschungszentrum Jülich GmbH, Jülich, Germany.ORCID http://orcid.org/0000-0001-5922-2685
Kazi A HossainDepartment of Physical Chemistry, Gdansk University of Technology, Narutowicza 11/12, Gdansk, Poland.ORCID http://orcid.org/0000-0002-1149-964X
Michał JurkowskiDepartment of Physical Chemistry, Gdansk University of Technology, Narutowicza 11/12, Gdansk, Poland.
Romain PouponLBPA, UMR8113 CNRS, ENS Paris-Saclay, Universite ́ Paris-Saclay, Gif-sur-Yvette, France.
Rahul SharmaInstitut de Mathématiques, École Polytechnique Fédérale de Lausanne, EPFL SB MATH LCVMM, Station 8, Lausanne, Switzerland.
Ran SunChemistry and Physics Programs, Louisiana Tech University, Ruston, LA, USA.
Thomas C BishopChemistry and Physics Programs, Louisiana Tech University, Ruston, LA, USA.ORCID http://orcid.org/0000-0003-4264-4261
Paolo CarloniComputational Biomedicine, Institute for Neuroscience and Medicine INM-9, Forschungszentrum Jülich GmbH, Jülich, Germany.ORCID http://orcid.org/0000-0002-9010-0149
Thomas E CheathamDepartment of Medicinal Chemistry, College of Pharmacy, University of Utah, Salt Lake City, UT, USA.
Rosana Collepardo-GuevaraYusuf Hamied Department of Chemistry, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0003-1781-7351
Jacek CzubDepartment of Physical Chemistry, Gdansk University of Technology, Narutowicza 11/12, Gdansk, Poland.ORCID http://orcid.org/0000-0003-3639-6935
Pablo D DansDepartment of Biological Sciences, CENUR Litoral Norte, Universidad de la República, Salto, Uruguay.ORCID http://orcid.org/0000-0002-5927-372X
Sarah A HarrisSchool of Mathematical and Physical Sciences, University of Sheffield, Hounsfield Road, Sheffield, UK.ORCID http://orcid.org/0000-0002-2812-1651
Charles LaughtonSchool of Pharmacy and Biodiscovery Institute, University of Nottingham, University Park, Nottingham, UK.ORCID http://orcid.org/0000-0003-4090-3960
Rodrigo Galindo-MurilloIonis Pharmaceuticals Inc., 2855 Gazelle Court, Carlsbad, CA, USA.ORCID http://orcid.org/0000-0001-5847-4143
John H MaddocksInstitut de Mathématiques, École Polytechnique Fédérale de Lausanne, EPFL SB MATH LCVMM, Station 8, Lausanne, Switzerland.
Agnes NoySchool of Physics, Engineering and Technology, University of York, York, UK.ORCID http://orcid.org/0000-0003-0673-8949
Alberto PérezDepartment of Chemistry and Quantum Theory Project, University of Florida, Gainesville, FL, USA.ORCID http://orcid.org/0000-0002-5054-5338
Daiva Petkevičiūtė-GerlachDepartment of Applied Mathematics, Kaunas University of Technology, Studentų, Kaunas, Lithuania.ORCID http://orcid.org/0000-0002-7646-2442
Modesto OrozcoInstitute for Research in Biomedicine (IRB Barcelona), Baldiri Reixac 10, Barcelona, Spain. modesto.orozco@irbbarcelona.org.ORCID http://orcid.org/0000-0002-8608-3278

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We present a tour de force of atomistic molecular dynamics simulations involving the coordinated effort of 14 research groups of the Ascona B-DNA Consortium (ABC). This initiative provides a complete characterization of the 2080 DNA hexamers embedded in 190 carefully selected 20-mer duplexes, each simulated in replicate for at least 10 microseconds in explicit solvent. The consortium generates 0.25 petabytes of data, capturing millisecond-scale ensembles at the oligomer level and dynamics up to 10

Indexed as

DNAMolecular Dynamics SimulationBase PairingNucleic Acid ConformationDNA

Identifiers

PMID42342657
PMCPMC13458730

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.