Evidence map›Paper›PMID 42342397›Full record

ArticleBMJ open2026

Fluorescence imaging using indocyanine green to identify sentinel lymph nodes during surgery for breast cancer (INFINITE): protocol for a hybrid effectiveness-implementation trial using a stepped-wedge cluster design.

Isabelle J Henskens, Tessa L Dinger, Iza Stekelenburg, Lea M Dijksman, Helena M Verkooijen, Emily L Postma, Annemiek Doeksen, Henk J Schuijt, INFINITE Study Group

Registry-linked trialAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07146295 (Implementation of Fluorescence Imaging Using Indocyanine Green to Identify Sentinel Lymph Nodes During Surgery for Breast Cancer), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07146295 narecruitingnot on this map

Implementation of Fluorescence Imaging Using Indocyanine Green to Identify Sentinel Lymph Nodes During Surgery for Breast Cancer

TypeinterventionalSponsorIsabelle HenskensRan2025 to 2026Enrolled1,760ConditionsBreast Cancer, Sentinel Lymph Node Biopsy (SLNB), Sentinel Lymph Node Detection, Sentinel Lymph NodeArmsTechnetium (99mTc), Indocyanine Green, Sentinel lymph node biopsy
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Isabelle J HenskensDepartment of Oncological Surgery, St Antonius Hospital, Nieuwegein, Utrecht, The Netherlands i.henskens@antoniusziekenhuis.nl.ORCID http://orcid.org/0009-0006-2914-5213
Tessa L DingerDepartment of Oncological Surgery, St Antonius Hospital, Nieuwegein, Utrecht, The Netherlands.
Iza StekelenburgDepartment of Oncological Surgery, St Antonius Hospital, Nieuwegein, Utrecht, The Netherlands.
Lea M DijksmanDepartment of Research and Innovation, St Antonius Hospital, Nieuwegein, Utrecht, The Netherlands.ORCID http://orcid.org/0000-0001-9227-1390
Helena M VerkooijenImaging Division Trial office, University Medical Centre Utrecht, Utrecht, The Netherlands.
Emily L PostmaDepartment of Oncological Surgery, St Antonius Hospital, Nieuwegein, Utrecht, The Netherlands.
Annemiek DoeksenDepartment of Oncological Surgery, St Antonius Hospital, Nieuwegein, Utrecht, The Netherlands.
Henk J SchuijtDepartment of Internal and Geriatric Medicine, Amsterdam University Medical Centres, Amsterdam, Noord-Holland, The Netherlands.
INFINITE Study Group

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionSentinel lymph node biopsy (SLNB) is the standard procedure for axillary staging in clinically node-negative breast cancer. Traditionally, SLNB is performed using technetium-labelled ( METHODS AND ANALYSIS: The INFINITE trial is a multicentre, hybrid effectiveness-implementation study employing a stepped-wedge cluster design across seven Dutch hospitals. Clusters sequentially transition from SLNB using ETHICS AND DISSEMINATION: Ethical approval was obtained from the Medical Research Ethics Committees United (6 November 2024; NL87551.100.24). Results will be submitted to open-access, peer-reviewed journals and presented at conferences focused on oncological or image-guided surgery. Implementation tools, including a clinical protocol, implementation guide, educational materials and patient information, will be developed to support national adoption. TRIAL REGISTRATION NUMBER: NCT07146295.

Indexed as

Breast NeoplasmsIndocyanine GreenOptical ImagingSentinel Lymph NodeSentinel Lymph Node BiopsyFemaleHumansMulticenter Studies as TopicNetherlandsIndocyanine GreenBreast imagingBreast surgeryBreast tumoursImplementation Science

Identifiers

PMID42342397
PMCPMC13295786

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.