Evidence map›Paper›PMID 42342144›Full record

ArticleEnvironmental pollution (Barking, Essex : 1987)2026

Perfluorooctanoic acid exposure disrupts gut microbiota and aggravates experimental colitis.

Dekun Cheng, Guangyi Shen, Jathya C Pathiranage, Yin Zhao, Junkai Xie, Qianyue Wang, Christina R Ferreira, Qingfei Zheng, Chongli Yuan, Weicang Wang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Environmental pollution (Barking, Essex : 1987), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Dekun ChengDepartment of Food Science, Purdue University, West Lafayette, IN, 47907, USA.
Guangyi ShenDepartment of Food Science, Purdue University, West Lafayette, IN, 47907, USA.
Jathya C PathiranageDepartment of Food Science, Purdue University, West Lafayette, IN, 47907, USA.
Yin ZhaoDavidson School of Chemical Engineering, Purdue University, West Lafayette, IN, 47907, USA.
Junkai XieDavidson School of Chemical Engineering, Purdue University, West Lafayette, IN, 47907, USA.
Qianyue WangBorch Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, West Lafayette, IN, 47907, USA.
Christina R FerreiraDepartment of Food Science, Purdue University, West Lafayette, IN, 47907, USA; Metabolite Profiling Facility, Bindley Bioscience Center, Purdue University, West Lafayette, IN, 47907, USA.
Qingfei ZhengBorch Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, West Lafayette, IN, 47907, USA.
Chongli YuanDavidson School of Chemical Engineering, Purdue University, West Lafayette, IN, 47907, USA.
Weicang WangDepartment of Food Science, Purdue University, West Lafayette, IN, 47907, USA. Electronic address: wang6205@purdue.edu.

Funding

Development of a Chemical Biology Toolbox to Investigate Histone MonoaminylationR35GM150676 · NIGMS · PURDUE UNIVERSITY · PI Qingfei Zheng · 2023 to 2026
$1.6M
NIGMS NIH HHS R35 GM150676
6 · The paper itself

Abstract

Perfluorooctanoic acid (PFOA), a prevalent and environmentally persistent compound in the per- and polyfluoroalkyl substance (PFAS) family, is ubiquitously detected in the food chain and has been epidemiologically linked to inflammatory bowel disease (IBD). However, the actions and mechanisms by which PFOA exposure influences colonic inflammation under colitis conditions remain incompletely understood. In this study, we investigated the impact of dietary PFOA exposure on colitis severity using a dextran sulfate sodium (DSS)-induced colitis model. Our results suggest that dietary PFOA exposure exacerbated colitis severity, as reflected by increased loss in body weight, colon shortening, and histopathological damage. Notably, PFOA exposure promoted colonic neutrophil infiltration and activation, characterized by increased expression of neutrophil markers, upregulation of neutrophil-recruiting chemokines, and enhanced expression of oxidative enzymes. PFOA also led to goblet cell depletion and reduced E-cadherin expression in colitis mice, indicating compromised integrity of epithelial barrier. Furthermore, fecal microbiome and metabolomic analyses revealed that PFOA exposure altered gut microbial composition and fecal metabolic profiles, which could be associated with the enhanced inflammatory outcomes observed during acute colitis. Collectively, these findings indicate that dietary PFOA exposure aggravates experimental colitis through coordinated neutrophil-mediated inflammation, epithelial barrier disruption, and microbiome-associated alterations. Our results highlight the potential role of PFOA as an environmental exacerbator of IBD and provide mechanistic insight into how its exposure influences host-microbiome interactions.

Indexed as

CaprylatesColitisEnvironmental PollutantsFluorocarbonsGastrointestinal MicrobiomeAnimalsDextran SulfateMaleMiceMice, Inbred C57BLCaprylatesDextran SulfateEnvironmental PollutantsFluorocarbonsperfluorooctanoic acidColitisFecal metabolitesGut microbiotaNeutrophilsPerfluorooctanoic acid

Identifiers

PMID42342144
PMCPMC13559703

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.