ArticleAnimal bioscience2026
Curcumin alleviates broiler liver damage caused by polybrominated diphenyl ether concurrent with restoring gut microbiota, reducing liver inflammation and endoplasmic reticulum stress.
Article in Animal bioscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectiveThe purpose of the present study was to evaluate the protective effects of curcumin (Cur) against broiler liver damage caused by exposure to polybrominated diphenyl ether (BDE-209).
methodsFour groups of 96 one-day-old broiler chicks were randomly assigned to the control group, the BDE-209 (0.4 g/kg) group, the BDE-209 (0.4 g/kg)+Cur (0.3 g/kg) group, or the Cur (0.3 g/kg) group. Following a 42-day treatment period, intestinal microbiota, hepatic inflammatory response, and endoplasmic reticulum stress were evaluated.
resultsBDE-209 caused severe intestinal damage, including shortened villi, increased crypt depth, disruption of tight junction structures, and ultrastructural abnormalities. Cur treatment alleviated these pathological changes, restoring tight junction protein expression and improving intestinal barrier function. Cur also cured BDE-209‑induced gut microbiota dysbiosis by increasing beneficial bacteria such as Lactobacillus and reducing harmful bacteria including Proteobacteria. Moreover, Cur lowered intestinal levels of key pro‑inflammatory cytokines. BDE‑209 caused significant liver damage, including histological lesions, hepatocyte ultrastructural damage, elevated blood liver enzymes, and oxidative stress. Cur improved liver function, lowered NF‑κB and MAPK signaling pathways, and reduced the expression of endoplasmic reticulum stress‑related proteins and genes.
conclusionCur alleviated BDE-209-induced liver damage in broilers while also restoring gut microbiota and reduction of inflammation, and endoplasmic reticula stress.
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