Evidence map›Paper›PMID 42341597›Full record

ArticleInternational dental journal2026

Predicting Perceived Profile Attractiveness From Cephalometric Measurements Using Machine Learning.

Zeynab Pirayesh, Fatemeh Sohrabniya, Seyed AmirHossein Ourang, Hossein Mohammad-Rahimi, Saharnaz Esmaeili, Sarvin Khosravani, Saeed Reza Motamedian, Falk Schwendicke, Antonin Tichy

Abstract read
In one paragraph

Article in International dental journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Zeynab PirayeshDepartment of Orthodontics and Dentofacial Orthopedics, School of Dentistry, Zanjan University of Medical Sciences, Zanjan, Iran; Topic Group Oral Health, ITU/WHO/WIPO Global Initiative on Artificial Intelligence for Health, Geneva, Switzerland.
Fatemeh SohrabniyaTopic Group Oral Health, ITU/WHO/WIPO Global Initiative on Artificial Intelligence for Health, Geneva, Switzerland; Department of Dentistry and Oral Health, Aarhus University, Aarhus, Denmark.
Seyed AmirHossein OurangDepartment of Orthodontics, School of Dentistry, Dentofacial Deformities Research Center, Research Institute of Dental Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Hossein Mohammad-RahimiTopic Group Oral Health, ITU/WHO/WIPO Global Initiative on Artificial Intelligence for Health, Geneva, Switzerland; Department of Dentistry and Oral Health, Aarhus University, Aarhus, Denmark; Department of Conservative Dentistry, Periodontology and Digital Dentistry, LMU University Hospital, Munich, Germany.
Saharnaz EsmaeiliDepartment of Orthodontics, School of Dentistry, Dentofacial Deformities Research Center, Research Institute of Dental Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Sarvin KhosravaniDepartment of Orthodontics, School of Dentistry, Dentofacial Deformities Research Center, Research Institute of Dental Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Saeed Reza MotamedianDepartment of Orthodontics, School of Dentistry, Dentofacial Deformities Research Center, Research Institute of Dental Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Electronic address: drmotamedian@gmail.com.
Falk SchwendickeTopic Group Oral Health, ITU/WHO/WIPO Global Initiative on Artificial Intelligence for Health, Geneva, Switzerland; Department of Conservative Dentistry, Periodontology and Digital Dentistry, LMU University Hospital, Munich, Germany.
Antonin TichyTopic Group Oral Health, ITU/WHO/WIPO Global Initiative on Artificial Intelligence for Health, Geneva, Switzerland; Department of Conservative Dentistry, Periodontology and Digital Dentistry, LMU University Hospital, Munich, Germany; Institute of Dental Medicine, First Faculty of Medicine, Charles University, Prague, Czech Republic.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesOrthodontic treatment planning requires careful consideration of facial aesthetics. This study aimed to compare machine learning (ML) models to predict perceived attractiveness based on lateral cephalometric measurements and to identify parameters that significantly impact perceived attractiveness.

methodsLateral cephalometric radiographs and corresponding facial photographs of 400 patients were utilized in this study. Twenty-six raters, including 20 laypeople and 6 domain experts (art, maxillofacial surgery, and orthodontics), evaluated each photograph using a 1 to 5 Visual Analogue Scale (VAS), and cephalometric analyses using the Dolphin software served as the reference standard. Five ML models, linear regression, Support Vector Machine, XGBoost Regressor, Random Forest, and artificial neural network, were trained to predict attractiveness scores based on the reference standard, and their performance on a test set (n = 59) was evaluated using root mean square error (RMSE). Subsequently, feature importance analysis was conducted to identify cephalometric indices that had the largest impact on VAS scores.

resultsExperts consistently rated facial attractiveness higher than laypeople, especially in age groups >15 years. Furthermore, female raters rated female profiles significantly higher and male profiles significantly lower than male raters, with differences evident in >15 age groups. Among the 5 ML models, Random Forest demonstrated the best performance (RMSE = 0.50). The feature importance analysis revealed that soft tissue parameters, especially those related to facial convexity, maxillary and mandibular prognathism, and vertical proportions, were most predictive of attractiveness scores.

conclusionML models showed promising results in predicting facial attractiveness based on cephalometric measurements and highlighted the correlation of facial aesthetics with soft tissue parameters. The proposed ML-based approach can aid clinicians in the objective assessment of treatment outcomes.

Indexed as

BeautyCephalometryEsthetics, DentalFaceMachine LearningAdolescentAdultBoosting Machine Learning AlgorithmsFemaleHumansMaleNeural Networks, ComputerPrediction AlgorithmsPredictive Learning ModelsRandom ForestSoft ComputingAestheticsArtificial intelligenceCephalometric analysisOrthodontics

Identifiers

PMID42341597
PMCPMC13319888

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.