Evidence map›Paper›PMID 42341137›Full record

ArticleScience advances2026

Distinct projections of PVN oxytocin neurons regulate the divergent defensive behaviors in response to social threat.

Chaobao Liu, Xixi Wang, Jindong Yao, Yuanyao Yang, Fan Wang, Yuan Li, Qiumin Le, Xing Liu, Lan Ma, Feifei Wang

Abstract read
In one paragraph

Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Chaobao LiuSchool of Basic Medical Sciences, State Key Laboratory of Brain Function and Disorders, MOE Frontiers Center for Brain Science, Institutes of Brain Science, Pharmacology Research Center, Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, China.ORCID 0000-0002-3049-713X
Xixi WangSchool of Basic Medical Sciences, State Key Laboratory of Brain Function and Disorders, MOE Frontiers Center for Brain Science, Institutes of Brain Science, Pharmacology Research Center, Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, China.ORCID 0009-0005-4585-387X
Jindong YaoSchool of Basic Medical Sciences, State Key Laboratory of Brain Function and Disorders, MOE Frontiers Center for Brain Science, Institutes of Brain Science, Pharmacology Research Center, Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, China.
Yuanyao YangSchool of Basic Medical Sciences, State Key Laboratory of Brain Function and Disorders, MOE Frontiers Center for Brain Science, Institutes of Brain Science, Pharmacology Research Center, Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, China.
Fan WangSchool of Basic Medical Sciences, State Key Laboratory of Brain Function and Disorders, MOE Frontiers Center for Brain Science, Institutes of Brain Science, Pharmacology Research Center, Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, China.ORCID 0009-0004-3746-1561
Yuan LiSchool of Basic Medical Sciences, State Key Laboratory of Brain Function and Disorders, MOE Frontiers Center for Brain Science, Institutes of Brain Science, Pharmacology Research Center, Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, China.ORCID 0009-0000-6164-0325
Qiumin LeSchool of Basic Medical Sciences, State Key Laboratory of Brain Function and Disorders, MOE Frontiers Center for Brain Science, Institutes of Brain Science, Pharmacology Research Center, Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, China.ORCID 0000-0002-2596-3052
Xing LiuSchool of Basic Medical Sciences, State Key Laboratory of Brain Function and Disorders, MOE Frontiers Center for Brain Science, Institutes of Brain Science, Pharmacology Research Center, Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, China.ORCID 0000-0002-9722-3109
Lan MaSchool of Basic Medical Sciences, State Key Laboratory of Brain Function and Disorders, MOE Frontiers Center for Brain Science, Institutes of Brain Science, Pharmacology Research Center, Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, China.ORCID 0000-0001-9034-5472
Feifei WangSchool of Basic Medical Sciences, State Key Laboratory of Brain Function and Disorders, MOE Frontiers Center for Brain Science, Institutes of Brain Science, Pharmacology Research Center, Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, China.ORCID 0000-0002-2351-6873

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The central oxytocin (OXT) system is involved in various aspects of social behavior and emotional regulation. However, the neuronal basis of the functional diversity of paraventricular nucleus (PVN) OXT neurons that modulate the defensive behaviors in response to social threat remains unclear. This study found that acute social defeat stress (ASDS) activates PVN OXT neurons in mice, promoting defensive behaviors during and after ASDS. When the mice were attacked, the nucleus accumbens (NAc)-projecting PVN OXT (OXT

Indexed as

Behavior, AnimalNeuronsOxytocinParaventricular Hypothalamic NucleusSocial BehaviorAnimalsCentral Amygdaloid NucleusMaleMiceMice, KnockoutNucleus AccumbensSocial DefeatStress, PsychologicalOxytocin

Identifiers

PMID42341137
PMCPMC13292991

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.