Evidence map›Paper›PMID 42341116›Full record

ArticleScience advances2026

FOLR1-targeted actinium-225-based alpha-particle therapy eliminates ovarian cancer.

Neetu Singh, Esther Need, Ayden Berndt, Matthew Goff, Lydia J Wilson, Firas Mourtada, Feng Guo, Tara Mastren, Taslim Al-Hilal, Anil K Sood and 5 more

Abstract read
In one paragraph

Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors.

Neetu SinghDepartment of Molecular Pharmaceutics, University of Utah, Salt Lake City, UT 84112, USA.ORCID 0009-0008-1824-1554
Esther NeedDepartment of Molecular Pharmaceutics, University of Utah, Salt Lake City, UT 84112, USA.ORCID 0009-0002-0060-5504
Ayden BerndtDepartment of Biomedical Engineering, University of Utah, Salt Lake City, UT 84112, USA.
Matthew GoffDepartment of Molecular Pharmaceutics, University of Utah, Salt Lake City, UT 84112, USA.
Lydia J WilsonDepartment of Radiation Oncology, Thomas Jefferson University, Philadelphia, PA 19107, USA.ORCID 0000-0002-9959-9310
Firas MourtadaDepartment of Radiation Oncology, Thomas Jefferson University, Philadelphia, PA 19107, USA.ORCID 0000-0002-4388-5334
Feng GuoDepartment of Pancreatic Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.ORCID 0000-0003-0882-5296
Tara MastrenDepartment of Civil and Environmental Engineering, University of Utah, Salt Lake City, UT 84112, USA.ORCID 0000-0003-1289-6505
Taslim Al-HilalDepartment of Molecular Pharmaceutics, University of Utah, Salt Lake City, UT 84112, USA.ORCID 0000-0002-9189-776X
Anil K SoodDepartment of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.ORCID 0000-0001-5458-2243
Amit MaityDepartment of Radiology Oncology, University of Utah, Salt Lake City, UT 84112, USA.
Scott C MillerDepartment of Radiology and Imaging Sciences, University of Utah, Salt Lake City, UT 84112, USA.ORCID 0000-0002-2127-1243
Satoshi MinoshimaDepartment of Radiology and Imaging Sciences, University of Utah, Salt Lake City, UT 84112, USA.
Shreya GoelDepartment of Molecular Pharmaceutics, University of Utah, Salt Lake City, UT 84112, USA.ORCID 0000-0001-8927-8380
Sixiang ShiDepartment of Molecular Pharmaceutics, University of Utah, Salt Lake City, UT 84112, USA.ORCID 0000-0002-8354-7620

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Despite the advancement in therapies, ovarian cancer treatment is challenging because of poor prognosis and high relapse associated with acquired resistance. Emerging targeted alpha particles, particularly actinium-225 (

Indexed as

ActiniumAlpha ParticlesFolate Receptor 1Ovarian NeoplasmsAnimalsCell Line, TumorFemaleHumansMicePositron-Emission TomographyXenograft Model Antitumor AssaysActiniumActinium-225Folate Receptor 1

Identifiers

PMID42341116
PMCPMC13292942

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.