Evidence map›Paper›PMID 42341106›Full record

ArticleScience advances2026

Common human ALDH1B1 and ALDH2 variants increase neuroinflammatory response to a single ethanol dose in mice.

Takuya Seike, Ruda Prestes E Albuquerque, Julio Cesar Batista Ferreira, Che-Hong Chen, Daria Mochly-Rosen

Abstract read
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In one paragraph

Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Takuya SeikeDepartment of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, CA 94305, USA.ORCID 0000-0002-4787-6910
Ruda Prestes E AlbuquerqueDepartment of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, CA 94305, USA.ORCID 0000-0002-7625-7123
Julio Cesar Batista FerreiraDepartment of Anatomy, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, 05508, Brazil.ORCID 0000-0003-2694-239X
Che-Hong ChenDepartment of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, CA 94305, USA.ORCID 0000-0003-0765-0893
Daria Mochly-RosenDepartment of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, CA 94305, USA.ORCID 0000-0002-6691-8733

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Unlike the well-documented effects of aldehyde dehydrogenase 2 (ALDH2) hypoactive variants, the impact of hypoactive ALDH1B1 has yet to be elucidated. Using the Global Human Genome Aggregation Database, we identified 38 ALDH1B1 variants, common (>0.1% allele frequency) to different human genetic ancestral groups. Some missense ALDH1B1 human variants are notably less active and less stable, and three variants represent a complete loss of function (LoF) due to early stop codon. Since these inactive variants are common among humans, we studied the impact of carrying both ALDH1B1 LoF and ALDH2 inactive variant in mice. Double knock-in (DKI) mice carrying ALDH1B1

Indexed as

Aldehyde Dehydrogenase 1 FamilyAldehyde Dehydrogenase, MitochondrialEthanolInflammationAnimalsGene Knock-In TechniquesHumansMiceAldehyde Dehydrogenase 1 FamilyAldehyde Dehydrogenase, MitochondrialALDH1B1 protein, humanALDH2 protein, humanALDH2 protein, mouseEthanol

Identifiers

PMID42341106
PMCPMC13292932

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.