Evidence map›Paper›PMID 42341085›Full record

ArticleScience translational medicine2026

IgA is necessary and sufficient to prevent norovirus infection in mice.

Arya B Ökten, Renata B Filler, Justin L Kung, Zhenhao Fang, Brieyanna C McWilliams, Jenna E Muscat-Rivera, Michael S Kegel, Ilze M Olivi Gomes, Madeleine C Mankowski, Ashwin N Skelly and 15 more

Abstract read
In one paragraph

Article in Science translational medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors.

Arya B ÖktenDepartment of Immunobiology, Yale School of Medicine, New Haven, CT 06510, USA.ORCID 0000-0002-7460-7951
Renata B FillerDepartment of Laboratory Medicine, Yale School of Medicine, New Haven, CT 06510, USA.ORCID 0000-0001-8579-8418
Justin L KungDepartment of Immunobiology, Yale School of Medicine, New Haven, CT 06510, USA.ORCID 0009-0002-6033-2659
Zhenhao FangDepartment of Genetics, Yale School of Medicine, New Haven, CT 06510, USA.ORCID 0000-0002-1246-3665
Brieyanna C McWilliamsDepartment of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.ORCID 0009-0006-7836-1836
Jenna E Muscat-RiveraDepartment of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.
Michael S KegelDepartment of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.ORCID 0009-0006-4155-9881
Ilze M Olivi GomesDepartment of Genetics, Yale School of Medicine, New Haven, CT 06510, USA.
Madeleine C MankowskiDepartment of Immunobiology, Yale School of Medicine, New Haven, CT 06510, USA.ORCID 0000-0002-8640-174X
Ashwin N SkellyDepartment of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.ORCID 0000-0002-1565-3376
Jilian R MelamedDepartment of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.ORCID 0000-0003-0364-9334
Timothy J NiceDepartment of Molecular Microbiology and Immunology, Oregon Health & Science University, Portland, OR 97239, USA.ORCID 0000-0002-4471-7666
Sanghyun LeeDepartment of Molecular Microbiology and Immunology, Brown University, Providence, PI 02912, USA.ORCID 0000-0002-0736-1648
Megan T BaldridgeDepartment of Medicine, Division of Infectious Diseases, Edison Family Center for Genome Sciences & Systems Biology, Washington University School of Medicine, Saint Louis, MO 63110, USA.ORCID 0000-0002-7030-6131
Thomas J SmithDepartment of Biochemistry and Molecular Biology, University of Texas Medical Branch at Galveston, Galveston, TX 77555, USA.ORCID 0000-0002-0978-1494
Christiane E WobusDepartment of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.ORCID 0000-0001-5286-0924
Stephanie C EisenbarthDepartment of Medicine, Division of Allergy and Immunology and the Center for Human Immunobiology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.ORCID 0000-0002-1244-208X
Adam WilliamsDepartment of Medicine, Division of Allergy and Immunology and the Center for Human Immunobiology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.ORCID 0000-0002-5151-4103
Leonid A SerebryannyyVaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Daniel C DouekVaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.ORCID 0000-0001-5575-8634
Drew WeissmanDepartment of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.ORCID 0000-0002-1501-6510
Sidi ChenDepartment of Genetics, Yale School of Medicine, New Haven, CT 06510, USA.ORCID 0000-0002-3819-5005
Edward F KreiderDepartment of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.ORCID 0000-0003-2330-8430
Joseph E CraftDepartment of Immunobiology, Yale School of Medicine, New Haven, CT 06510, USA.ORCID 0000-0002-1368-6756
Craig B WilenDepartment of Immunobiology, Yale School of Medicine, New Haven, CT 06510, USA.ORCID 0000-0003-2495-9403

Funding

INTERDISCIPLINARY IMMUNOLOGY TRAINING PROGRAMT32AI007019 · NIAID · YALE UNIVERSITY · PI Carrie L. Lucas, David G. Schatz · 1985 to 2026
$14.4M
IMMUNE RESPONSES IN LUPUSR37AR040072 · NIAMS · YALE UNIVERSITY · PI CRAFT, JOSEPH EDGAR · 2000 to 2025
$7.4M
The role of tuft cells in norovirus pathogenesisR01AI148467 · NIAID · YALE UNIVERSITY · PI Craig Brian Wilen · 2020 to 2026
$3.9M
Determinants of oral anaphylaxis to foodR01AI168016 · NIAID · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Stephanie Caroline Eisenbarth, ADAM WILLIAMS · 2023 to 2026
$3.2M
Role of norovirus capsid dynamics in adaptive immune evasionR01AI189484 · NIAID · UNIVERSITY OF TEXAS MED BR GALVESTON · PI SMITH, THOMAS JAMES., WOBUS, CHRISTIANE · 2025 to 2025
$2.9M
Viral immune evasion during intestinal norovirus infectionR01AI183155 · NIAID · BROWN UNIVERSITY · PI Sanghyun Lee · 2024 to 2026
$1.7M
A multipronged, mRNA gene therapy approach to HIV cureDP2AI184637 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI Edward Kreider · 2025 to 2026
$972k
NIAID NIH HHS DP2 AI184637NIAID NIH HHS R01 AI148467NIAID NIH HHS R01 AI168016NIAID NIH HHS R01 AI183155NIAID NIH HHS R01 AI189484NIAID NIH HHS T32 AI007019NIAMS NIH HHS R37 AR040072Wellcome Trust
6 · The paper itself

Abstract

Human norovirus is the leading cause of viral gastroenteritis, yet effective vaccines and therapeutics remain elusive. Using murine norovirus as a model, we found that mucosal immunoglobulin A (IgA) is both necessary and sufficient for protection against infection, whereas CD8

Indexed as

Caliciviridae InfectionsImmunoglobulin ANorovirusAnimalsAntibodies, ViralCD8-Positive T-LymphocytesHumansImmunoglobulin GMiceMice, Inbred C57BLAntibodies, ViralImmunoglobulin AImmunoglobulin G

Identifiers

PMID42341085
PMCPMC13537108

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.