ArticleSTAR protocols2026
Protocol for enhancing production of human PSC-derived cardiomyocytes and endothelial cells with placental growth factor.
Article in STAR protocols, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Authors and funding
4 authors.
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Abstract
Placental growth factor (PLGF) drives cardiomyogenesis and vasculogenesis during cardiogenesis. Here, we present a protocol for enhancing production of human pluripotent stem cell (hPSC)-derived cardiomyocytes (CMs) and endothelial cells (ECs). We describe steps for CM-/EC-directed hPSC differentiation with PLGF. Our approaches can achieve production of hPSC-CMs/-ECs by 2- to 2.5-fold compared with those in traditionally established protocols, through promoting proliferation and differentiation of cardiac and vascular progenitors. For complete details on the use and execution of this protocol, please refer to Witman et al.
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Registered trials
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