SynthesisEuropean thyroid journal2026
The effect of iodinated contrast media on thyroid (dys)function in children.
Synthesis in European thyroid journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
3 authors.
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Abstract
backgroundExcess iodine from iodinated contrast media (ICM) can lead to thyroid dysfunction. Children, especially neonates and premature infants, may be more vulnerable due to their immature thyroid physiology.
methodsA systematic review was conducted using EMBASE, MEDLINE (PubMed), Cochrane, Web of Science, and Scopus. Inclusion criteria were studies in children ≤ 18 years receiving ICM and that reported effects on thyroid function. Exclusion criteria included topical iodine exposure, prenatal administration, and irrelevant endpoints. Case reports, reviews, and abstracts were also excluded.
resultsMost studies reported temporary thyroid function disturbances following ICM exposure in children, particularly subclinical hypothyroidism. Overt hypothyroidism was rare and occurred mainly in neonates and high-risk groups. In certain studies, up to 25% of neonates showed TSH abnormalities, with a subset requiring levothyroxine treatment. Although even more rare, some studies also reported cases of thyrotoxicosis after ICM exposure.
conclusionICM exposure can lead to thyroid dysfunction in children, especially in neonates, preterm infants, and those with risk factors. Risk-based screening and monitoring are recommended to allow timely detection and treatment.
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