ArticleMolecular biology reports2026
Protective role of ginger nanoparticles against hepatocellular carcinoma through regulation of DNA methylation and miRNA-34a-mediated apoptosis.
Article in Molecular biology reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHepatocellular carcinoma (HCC) is a common, aggressive, and potentially fatal malignancy. Ginger possesses a wide range of beneficial biological effects on different body organs. The present study investigated the therapeutic effects of ginger extract (GE) and ginger nanoparticles (GNPs) against HCC induced by diethylnitrosamine (DEN) and carbon tetrachloride (CCl₄).
methodsTreatment was initiated 15 weeks after HCC induction and continued for six consecutive weeks. Forty rats were equally divided into four groups. Group 1 (normal control): rats received saline; Group 2 (DEN/CCl₄): HCC-induced rats; Group 3 (HCC + GE): HCC-induced rats treated with ginger extract (300 mg/kg body weight/day); and Group 4 (HCC + GNPs): HCC-induced rats treated with ginger nanoparticles (50 mg/kg body weight/day). Liver function enzymes and gene expression levels were assessed in blood and tissue samples.
resultsThe HCC-induced group showed a significant elevation in liver marker enzymes, global DNA hypermethylation, upregulation of HAT1 and HDAC4, and downregulation of miRNA-34a expression. In contrast, treatment with GE or GNPs resulted in significant global DNA hypomethylation, downregulation of HAT1 and HDAC4, and upregulation of hepatic miRNA-34a expression.
conclusionThe findings suggest that GE and GNPs suppress hepatocarcinogenesis, potentially through activation of the miRNA-34a pathway involved in apoptosis regulation.
Indexed as
Identifiers
42340577What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.