Evidence map›Paper›PMID 42340543›Full record

ArticleInternational journal of implant dentistry2026

In vitro analysis of a glass solder matrix on ATZ-ceramic-samples using human dental pulp cells and L929 mouse fibroblasts.

Sandra Fuest, Moritz L Dyck, Mustafa Becerikli, Andreas Schmoock, Anders Henningsen, Christian Moss, Robert Mau, Hermann Seitz, Reinhard E Friedrich, Martin Gosau and 2 more

Abstract read
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In one paragraph

Article in International journal of implant dentistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Sandra FuestDepartment of Oral and Maxillofacial Surgery, Division of Regenerative Orofacial Medicine, University Medical Center Hamburg-Eppendorf, 20246, Hamburg, Germany.
Moritz L DyckDepartment of Oral and Maxillofacial Surgery, University Medical Center Hamburg-Eppendorf, 20246, Hamburg, Germany.
Mustafa BecerikliDepartment of Plastic Surgery, BG University Hospital Bergmannsheil, Ruhr-University Bochum, 44789, Bochum, Germany.
Andreas SchmoockDepartment of Oral and Maxillofacial Surgery, Division of Regenerative Orofacial Medicine, University Medical Center Hamburg-Eppendorf, 20246, Hamburg, Germany.
Anders HenningsenDepartment of Oral and Maxillofacial Surgery, Division of Regenerative Orofacial Medicine, University Medical Center Hamburg-Eppendorf, 20246, Hamburg, Germany.
Christian MossDental Laboratory Moss, 20097, Hamburg, Germany.
Robert MauChair of Microfluidics, University of Rostock, 18059, Rostock, Germany.
Hermann SeitzChair of Microfluidics, University of Rostock, 18059, Rostock, Germany.
Reinhard E FriedrichDepartment of Oral and Maxillofacial Surgery, University Medical Center Hamburg-Eppendorf, 20246, Hamburg, Germany.
Martin GosauDepartment of Oral and Maxillofacial Surgery, University Medical Center Hamburg-Eppendorf, 20246, Hamburg, Germany.
Ralf SmeetsDepartment of Oral and Maxillofacial Surgery, Division of Regenerative Orofacial Medicine, University Medical Center Hamburg-Eppendorf, 20246, Hamburg, Germany.
Levi MatthiesDepartment of Oral and Maxillofacial Surgery, University Medical Center Hamburg-Eppendorf, 20246, Hamburg, Germany. l.matthies@uke.de.ORCID https://orcid.org/0000-0001-7168-4428

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeOptimized surface properties are a pivotal factor for dental ceramic implants and overall implant success. After grit-blasting and spray-coating Aluminum Toughened Zirconia (ATZ) ceramic samples with a glass solder, the biological cell response was examined and compared to uncoated and solely grit-blasted samples of the same ceramic.

methodsIn this study, a silica-based glass solder was evaluated for cytocompatibility, osteogenic differentiation, and hemocompatibility using L929 mouse fibroblasts and human dental pulp cells (HDPCs).

resultsNo toxic effects were observed for either coated or uncoated ATZ samples in direct or indirect tests, as assessed by live/dead staining. Differentiation and viability assays with HDPCs and L929 mouse fibroblasts showed no toxicity, and osteogenic differentiation was not impaired by the coating. Hemocompatibility testing with human whole blood revealed similar results for coated and uncoated ceramic specimens, with no hemolysis or adverse effects on standard hematological parameters.

conclusionsThe glass solder coating was cytocompatible and hemocompatible under the tested in vitro conditions and did not impede osteogenic differentiation. These findings indicate that it can serve as a suitable substrate for the proliferation and spreading of L929 fibroblasts and HDPCs, with potential benefits for improving dental ceramic implant surfaces.

Indexed as

CeramicsDental PulpFibroblastsGlassZirconiumAnimalsCell DifferentiationHumansIn Vitro TechniquesMaterials TestingMiceOsteogenesisSurface PropertiesZirconiumzirconium oxideCeramic implantDental implantGlass matrixGlass solderSurface modificationZirconium

Identifiers

PMID42340543
PMCPMC13294409

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.