ArticleMolecular biology reports2026
Antibiofilm and antivirulence effects of cinnamaldehyde on Acinetobacter baumannii.
Article in Molecular biology reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAcinetobacter baumannii is a multidrug-resistant pathogen known for its robust biofilm formation, leading to persistent infections and treatment failure. Traditional antibiotics often struggle to penetrate these biofilms. Cinnamaldehyde, a plant-derived antimicrobial compound, holds potential as an antibiofilm agent. This study investigates its effects on biofilm formation, EPS production, cell surface properties, oxidative stress response, and gene expression in A. baumannii.
methodsThis study evaluated the antibiofilm activity of cinnamaldehyde using A. baumannii. Biofilm formation was quantified via crystal violet assay, while structural alterations were visualised using light microscopy, SEM, and CLSM. EPS production and cell surface hydrophobicity were evaluated using phenol-sulfuric acid and MATH assays. Catalase activity was assessed through H₂O₂ sensitivity, and qRT-PCR analysed gene expression. Cytotoxicity was evaluated using the MTT assay on mouse fibroblast cells.
resultsCinnamaldehyde significantly inhibited biofilm formation, with 86.67% reduction at 0.007% (v/v), without affecting planktonic growth. Microscopy revealed disrupted biofilm architecture and reduced microcolony formation. SEM showed reduced EPS and altered cell morphology. EPS quantification confirmed a 33.06% reduction. Cell surface hydrophobicity decreased from 86.76% to 21.93%, impairing bacterial adhesion. H₂O₂ sensitivity increased, indicating reduced catalase activity. Gene expression analysis showed downregulation of bfmR, ompA, csuA/B, and katE. Cinnamaldehyde showed minimal cytotoxicity in mouse fibroblast cells.
conclusionCinnamaldehyde effectively inhibits A. baumannii biofilms through structural disruption, EPS reduction, altered surface hydrophobicity, oxidative stress sensitization, and gene suppression. Its non-toxic nature and broad mechanisms highlight its potential as a plant-based antibiofilm agent for controlling resistant infections.
Indexed as
Identifiers
42340487What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.