ReviewMedizinische Klinik, Intensivmedizin und Notfallmedizin2026
[Invasive mechanical ventilation: indications and alternatives : Systematic evaluation of the evidence and recommendations for clinical practice from the S3 guidelines "invasive mechanical ventilation and the use of extracorporeal procedures in acute respiratory failure"].
Review in Medizinische Klinik, Intensivmedizin und Notfallmedizin, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSelecting the appropriate mode of respiratory support in cases of acute respiratory failure is clinically challenging and has relevant implications for patient outcomes. Despite the widespread use of noninvasive techniques, uncertainties remain regarding optimal indications, timing of escalation and patient-centered aspects. AIM OF THIS STUDY: This paper summarizes the chapter on interpretation of indications and alternatives to invasive mechanical ventilation from the German S3 clinical guidelines "invasive ventilation and extracorporeal life support in acute respiratory failure".
methodsFor the guideline revision a systematic literature search and critical appraisal were conducted, including national and international guidelines. Recommendations were developed using the evidence to decision framework and a consensus was reached in several conferences.
resultsNoninvasive respiratory support, including noninvasive ventilation (NIV) and high-flow nasal oxygen (HFNO), is effective in patients with moderate impairment of oxygenation (PaO DISCUSSION: The available evidence supports an individualized approach to the choice of respiratory support that incorporates patients' preferences. Key elements include a regular reassessment, avoidance of delayed intubation, adequate personnel and expert resources and transparent communication within the interdisciplinary treatment team.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.