ArticleVirchows Archiv : an international journal of pathology2026
Gallbladder MiNEN arising in association with an intracholecystic papillary neoplasm exhibiting divergent p53 expression.
Article in Virchows Archiv : an international journal of pathology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mixed neuroendocrine-non-neuroendocrine neoplasms (MiNENs) of the biliary tract are exceptionally rare and predominantly involve the gallbladder (GB). Their reported association with precursor epithelial lesions raises important questions regarding histogenesis. We report the case of a 74-year-old woman who underwent cholecystectomy for calculus-associated carcinoma. Histological examination revealed a heterogeneous neoplasm composed of three intimately admixed components: an intracholecystic papillary neoplasm (ICPN), a large cell neuroendocrine carcinoma (LCNEC), and a pancreatobiliary-type adenocarcinoma. Both the ICPN and adenocarcinoma components exhibited aberrant p53 immunostaining, whereas the LCNEC showed a wild-type pattern. All components were mismatch repair proficient and demonstrated membranous β-catenin expression. In line with previous reports, this case further suggests that ICPN may represent a common precursor lesion with the potential for divergent differentiation to GB MiNEN. The discordant p53 profiles observed across tumor components may be further explained by clonal evolution and intratumoral heterogeneity.
Indexed as
Identifiers
42340387What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.