ArticleVirchows Archiv : an international journal of pathology2026
Penile squamous cell carcinomas with the usual-type morphology can be HPV-associated - Routine p16/HPV testing should be performed in all penile squamous cell carcinomas regardless of morphology.
Article in Virchows Archiv : an international journal of pathology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Pilomatrix-like high grade carcinomas involving urinary bladder: a novel divergent differentiation in urothelial carcinoma.Virchows Archiv : an international journal of pathology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Usual-type penile squamous cell carcinoma (pSCC) is the most common pSCC subtype, categorized under the HPV-independent pSCC category in the WHO classification. Currently, guidelines do not explicitly recommend routine HPV testing in pSCCs, and pSCCs with the usual-type morphology are often presumed to be HPV-independent without further testing. This study investigates the HPV status in pSCCs with the usual-type morphology. Fifteen consecutive pSCCs with the usual-type morphology were retrospectively identified. p16 immunohistochemistry was diffusely positive in three of the fifteen pSCCs with the usual-type morphology (3/15; 20%), confirmed by high-risk HPV in situ hybridization. As routine HPV testing is not explicitly recommended in the pSCCs with the usual-type morphology, there could be a significant number of the pSCCs incorrectly presumed to be HPV-independent. As the HPV status in pSCCs carries significant clinical consequences, routine HPV testing should be considered in all pSCCs with the usual-type morphology.
Indexed as
Identifiers
42340386What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.