Evidence map›Paper›PMID 42340301›Full record

ArticleJournal of Alzheimer's disease : JAD2026

Interleukin-6 is associated with white matter hyperintensities and cognition independent of Alzheimer's disease plasma biomarkers-HABS-HD.

Anhiti Dharmapuri, Soumilee Chaudhuri, Joey Annette Contreras, Cellas A Hayes, Health and Aging Brain Study (HABS-HD) Study Team *

Abstract read
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In one paragraph

Article in Journal of Alzheimer's disease : JAD, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Anhiti DharmapuriDepartment of Psychiatry, Healthy Brain Aging Sleep Center, NYU Grossman School of Medicine, New York, NY, USA.
Soumilee ChaudhuriDepartment of Radiology and Imaging Sciences, Center for Neuroimaging, Indiana University School of Medicine, Indianapolis, IN, USA.
Joey Annette ContrerasDepartment of Neurosciences, Alzheimer's Disease Cooperative Study, University of California San Diego, San Diego, CA, USA.
Cellas A HayesStanford University School of Medicine Department of Epidemiology and Population Health, Stanford University, Palo Alto, CA, USA.ORCID 0000-0002-6259-9456
Health and Aging Brain Study (HABS-HD) Study Team *

Funding

The Health & Aging Brain Study - Health Disparities (HABS-HD)U19AG078109 · NIA · UNIVERSITY OF NORTH TEXAS HLTH SCI CTR · PI LEIGH A JOHNSON, Sid E O'Bryant · 2022 to 2026
$181.1M
Health and Aging Brain among Latino Elders (HABLE-AT(N)) StudyR01AG058533 · NIA · UNIVERSITY OF NORTH TEXAS HLTH SCI CTR · PI JOHNSON, LEIGH A, O'BRYANT, SID E · 2020 to 2025
$45.4M
TR&D3: Intrinsic Surface MappingP41EB015922 · NIBIB · UNIVERSITY OF SOUTHERN CALIFORNIA · PI VAN HORN, JOHN DARRELL · 2012 to 2022
$14.1M
Health Disparities in Alzheimer's Disease and Mild Cognitive Impairment among Mexican AmericansR01AG054073 · NIA · UNIVERSITY OF NORTH TEXAS HLTH SCI CTR · PI O'BRYANT, SID E, TOGA, ARTHUR W · 2017 to 2021
$12.6M
NIA NIH HHS R01 AG054073NIA NIH HHS R01 AG058533NIA NIH HHS U19 AG078109NIBIB NIH HHS P41 EB015922
6 · The paper itself

Abstract

BackgroundChronic inflammation contributes to neurodegeneration and cerebrovascular injury, yet it remains unclear whether inflammatory biomarkers influence white matter hyperintensity (WMH) volume and cognition independent of Alzheimer's disease (AD) plasma biomarkers.ObjectiveThis study examined whether inflammatory biomarkers were associated with WMH volume and multidomain cognitive performance independent of AD plasma biomarkers, and whether WMH volume mediated associations between IL-6 and cognition.MethodsUsing data from 1806 participants in the Health and Aging Brain Study-Health Disparities (HABS-HD), we examined associations between log transformed plasma inflammatory biomarkers (IL-10, TNF-α, IL-6, and IL-5) and WMH volume and cognitive performance (memory, executive function, processing speed, language). Multivariable linear regression models adjusted for demographic and vascular risk factors were repeated with additional adjustment for AD biomarkers (p-Tau181, NfL, total tau, Aβ

Indexed as

Alzheimer DiseaseCognitionInterleukin-6White MatterAgedAged, 80 and overBiomarkersFemaleHumansMagnetic Resonance ImagingMaleNeuropsychological TestsBiomarkersIL6 protein, humanInterleukin-6Alzheimer's diseasecognitionexecutive functioninterleukin-6memoryneurofilament lightwhite matter hyperintensities

Identifiers

PMID42340301
PMCPMC13297475

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.