ArticlemBio2026
Loss of essential outer membrane functions causes drug hypersensitization in
Efrat Hamami, Wenwen Huo, Katherine Neal, Isabelle Neisewander, Shivangi, Joel S Freundlich, Edward Geisinger, Ralph R Isberg
Abstract read
In one paragraphArticle in mBio, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
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4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
8 authors.
Efrat HamamiDepartment of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, Massachusetts, USA.ORCID 0009-0008-1950-3587 Wenwen HuoDepartment of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, Massachusetts, USA.
Katherine NealDepartment of Biochemistry, Curry College, Milton, Massachusetts, USA.
Isabelle NeisewanderDepartment of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, Massachusetts, USA.
ShivangiDepartment of Pharmacology, Physiology, and Neuroscience, Rutgers University-New Jersey Medical School, Newark, New Jersey, USA.
Joel S FreundlichDepartment of Pharmacology, Physiology, and Neuroscience, Rutgers University-New Jersey Medical School, Newark, New Jersey, USA.
Edward GeisingerDepartment of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, Massachusetts, USA.ORCID 0000-0001-9661-8072 Ralph R IsbergDepartment of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, Massachusetts, USA.ORCID 0000-0002-8330-3554 Funding
Innovative technologies to transform antibiotic discovery. Project 4 Infection site-specific amplification of antimicrobial conjugatesU19AI142780 · NIAID · BROAD INSTITUTE, INC. · PI BLAINEY, PAUL CLARK · 2019 to 2023
$33.9MTherapeutics for drug-resistant bacteria: arylmyxopyroninsU19AI189168 · NIAID · HACKENSACK UNIVERSITY MEDICAL CENTER · PI David S Perlin · 2025 to 2026
$22.7MPredicting the emergence of antibiotic resistance through multi-omics approaches and Immune System-surveillanU01AI124302 · NIAID · BOSTON COLLEGE · PI BENTO, JOSE, COOPER, VAUGHN · 2016 to 2020
$10.2MDrug resistance enablers and their role in antibiotic treatment failureU19AI158076 · NIAID · BROAD INSTITUTE, INC. · PI COOPER, VAUGHN, ISBERG, RALPH R. · 2022 to 2025
$10.0MIdentification of the Achilles’ heel in Acinetobacter fluoroquinolone-resistant mutantsR21AI128328 · NIAID · TUFTS UNIVERSITY BOSTON · PI ISBERG, RALPH R. · 2017 to 2018
$454kNational Institute of Allergy and Infectious Diseases U01AI124302, U19AI158076, R21AI128328, U19AI142780National Institute of Allergy and Infectious Diseases U19AI189168NIAID NIH HHS R21 AI128328NIAID NIH HHS U01 AI124302NIAID NIH HHS U19 AI142780NIAID NIH HHS U19 AI158076NIAID NIH HHS U19 AI189168
6 · The paper itselfAbstract
Elevated expression of resistance-nodulation-cell division (RND) drug transporters is commonly observed in clinical isolates of IMPORTANCE:
Indexed as
Acinetobacter baumanniiAnti-Bacterial AgentsBacterial Outer MembraneBacterial Outer Membrane ProteinsDrug Resistance, Multiple, BacterialMembrane Transport ProteinsBacterial ProteinsCiprofloxacinGenes, EssentialMicrobial Sensitivity TestsAnti-Bacterial AgentsBacterial Outer Membrane ProteinsBacterial ProteinsCiprofloxacinMembrane Transport ProteinsAcinetobacter baumanniiantimicrobial combinationsCRISPRimultidrug resistanceRND efflux pumps
Identifiers
PMID42339869
PMCPMC13463702
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