Evidence map›Paper›PMID 42339862›Full record

ArticleMicrobiology spectrum2026

Development and

Rizka O A Jariah, Jennifer Schofield, Kevin West, Karen D Adler, Slawomir Michniewski, Caitlin Wildsmith, Eleanor Jameson, Lucy Onions, Faizal Patel, Anusha Saravanan and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Microbiology spectrum, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Phage therapy againstFrontiers in microbiology · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Rizka O A JariahBecky Meyer Center for Phage Research, Division of Microbial and Infection, School of Biological and Biomedical Sciences, College of Life Sciences, University of Leicester, Leicester, United Kingdom.ORCID 0000-0002-6934-6953
Jennifer SchofieldLeicester Drug Discovery and Diagnostics, University of Leicester, Leicester, United Kingdom.
Kevin WestUniversity Hospitals of Leicester NHS Trust, Leicester, United Kingdom.
Karen D AdlerBecky Meyer Center for Phage Research, Division of Microbial and Infection, School of Biological and Biomedical Sciences, College of Life Sciences, University of Leicester, Leicester, United Kingdom.
Slawomir MichniewskiBecky Meyer Center for Phage Research, Division of Microbial and Infection, School of Biological and Biomedical Sciences, College of Life Sciences, University of Leicester, Leicester, United Kingdom.
Caitlin WildsmithBecky Meyer Center for Phage Research, Division of Microbial and Infection, School of Biological and Biomedical Sciences, College of Life Sciences, University of Leicester, Leicester, United Kingdom.
Eleanor JamesonSchool of Environmental and Natural Sciences, Bangor University, Bangor, United Kingdom.ORCID 0000-0001-6427-3794
Lucy OnionsDivision of Biomedical Services, University of Leicester, Leicester, United Kingdom.
Faizal PatelBecky Meyer Center for Phage Research, Division of Microbial and Infection, School of Biological and Biomedical Sciences, College of Life Sciences, University of Leicester, Leicester, United Kingdom.
Anusha SaravananBecky Meyer Center for Phage Research, Division of Microbial and Infection, School of Biological and Biomedical Sciences, College of Life Sciences, University of Leicester, Leicester, United Kingdom.
Hasan YesilkayaDivision of Microbiology and Infection, School of Biological and Biomedical Sciences, College of Life Sciences, University of Leicester, Leicester, United Kingdom.
Spyridon MegremisBecky Meyer Center for Phage Research, Division of Microbial and Infection, School of Biological and Biomedical Sciences, College of Life Sciences, University of Leicester, Leicester, United Kingdom.
Andrew D MillardBecky Meyer Center for Phage Research, Division of Microbial and Infection, School of Biological and Biomedical Sciences, College of Life Sciences, University of Leicester, Leicester, United Kingdom.
Martha R J ClokieBecky Meyer Center for Phage Research, Division of Microbial and Infection, School of Biological and Biomedical Sciences, College of Life Sciences, University of Leicester, Leicester, United Kingdom.ORCID 0000-0002-6069-8936
Melissa E K HainesBecky Meyer Center for Phage Research, Division of Microbial and Infection, School of Biological and Biomedical Sciences, College of Life Sciences, University of Leicester, Leicester, United Kingdom.ORCID 0000-0002-5788-1211

Funding

Medical Research Council MR/T030062/1, MR/L015080/1Medical Research Council MR/X502777/1
6 · The paper itself

Abstract

Uropathogenic IMPORTANCE: The emergence of antibiotic resistance, coupled with a slow development of new antimicrobials, has renewed the interest in phage therapy, including for the treatment of urinary tract infections (UTIs). Despite the growing number of animal studies evaluating phage therapy, UTIs remained relatively understudied in this context. Here, we established a robust acute UTI murine model and used it to assess the efficacy of our optimized Leicester-UTI1 phage cocktail targeting extended-spectrum β-lactamase-associated

Indexed as

BacteriophagesKlebsiella InfectionsKlebsiella pneumoniaePhage TherapyUrinary Tract InfectionsAnimalsAnti-Bacterial Agentsbeta-LactamasesDisease Models, AnimalFemaleHumansMiceMice, Inbred C57BLAnti-Bacterial Agentsbeta-Lactamasesantimicrobial resistanceimmune responsephage therapyurinary tract infection

Identifiers

PMID42339862
PMCPMC13436347

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.