ArticleTurkish journal of ophthalmology2026
Determination of the Non-Invasive Tear Break-Up Time Cut-Off Point for Diagnosis of Dry Eye Disease and Its Correlation with Other Dry Eye Tests.
Article in Turkish journal of ophthalmology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objectives: To determine optimal cut-off values for first and average non-invasive tear break-up time (NIBUT-f and NIBUT-av, respectively) in dry eye disease (DED), as well as evaluate their correlation with other tests. Materials and Methods: This retrospective study included 46 patients with DED and 35 healthy controls. All subjects were assessed using the Ocular Surface Disease Index questionnaire. NIBUT measurements and meibography images were obtained using the Sirius topography device. The conventional diagnostic tests Schirmer-I, tear break-up time (TBUT), ocular surface staining (OSS), Marx line score, and lid wiper epitheliopathy (LWE) grade were performed. Results: The cut-off values of NIBUT-f and NIBUT-av for DED diagnosis were identified as 10.7 and 12.2 seconds, respectively. The area under the curve (AUC) was 0.93 (95% confidence interval [CI]: 0.889-0.992) for NIBUT-f and 0.92 (95% CI: 0.872-0.985) for NIBUT-av. For the differentiation between evaporative and mixed DED subtypes, the NIBUT-av cut-off value was 7.2 seconds, with an AUC of 0.63 (95% CI: 0.512-0.743). NIBUT-av showed a positive correlation with TBUT (p<0.001, r=0.905) and Schirmer-I (p<0.001, r=0.403) but a negative correlation with OSS (p<0.001, r=-0.700), meibomian gland loss (p<0.001, r=-0.601), LWE grade (p<0.001, r=-0.597), and Marx line score (p<0.001, r=-0.539). Conclusion: NIBUT is a highly sensitive and specific non-invasive diagnostic tool for DED that correlates with other ocular surface and meibomian gland function tests.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.