ArticleFrontiers in neurology
Mechanism of electrothermal acupuncture in alleviating postherpetic neuralgia.
Article in Frontiers in neurology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Purpose: To investigate the mechanism of electrothermal acupuncture in alleviating postherpetic neuralgia (PHN). Patients and methods: A rat model of PHN was created with RTX injection, and electrothermal acupuncture (ETA) was applied at trigger points. Pain sensitivity was assessed using the von Frey test for PWT. ATP levels were measured colorimetrically, ROS via DCFH-DA fluorescence, and pro-inflammatory cytokines (TNF- Results: ETA significantly increased PWT values, confirming its analgesic effect. Moreover, compared to the PHN group, ETA treatment significantly attenuated RXT-induced increases in the levels of IL-1β, IL-6, and TNF- Conclusion: ETA alleviates tactile allodynia induced by RTX in rats, at least in part by upregulating the expression of type I interferon-related genes (Mx1, Irf7, Rtp4, Oasl2, and Ifit1bl). This upregulation suppresses the central and peripheral inflammatory responses associated with PHN, while also modulating energy metabolism and redox homeostasis in pain-related tissues. These findings offer novel mechanistic insights supporting the use of ETA as an adjunctive therapy for neuropathic pain management.
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