ArticleFrontiers in plant science2026
Integrated metabolomics, network pharmacology and molecular docking to reveal the effects of drying processes on the antioxidant activity of mulberry (
Article in Frontiers in plant science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Abstract
Introduction: Mulberry ( Methods: A comprehensive approach based on UPLC-MS/MS metabolomics, network pharmacology and molecular docking was employed to find the active compounds in MLs treated by different drying methods and their potential antioxidant mechanisms in this study. Results and discussion: A total of 1467 metabolites were detected through UPLC-MS/MS analysis, and differential metabolites of MLs were searched by multivariate statistical analysis. Hot-air dried MLs exhibited the highest DPPH and ABTS radical scavenging capacities, as well as the strongest ferric reducing antioxidant power. This enhanced activity might be attributed to the maximal hydrolysis of kaempferol glycosides, leading to the significant accumulation of free kaempferol. Network pharmacology analysis further revealed that the bioactive compounds in MLs exerted their antioxidant effects by targeting key proteins, including AKT1, TNF, ALB, IL-1B, and BCL2. These findings provided valuable insights into how different drying methods influenced the antioxidant property of MLs.
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