ArticleEvolution, medicine, and public health2026
Built environment is a key driver of cardiometabolic health in two Indigenous groups undergoing rapid lifestyle change.
Article in Evolution, medicine, and public health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Divergent biological consequences of APOE isoforms across industrialized and non-industrial environments.PLoS genetics · 2026Article
- Physical activity and cardiometabolic health across an extreme lifestyle gradient.Evolution, medicine, and public health · 2026Article
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23 authors.
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Abstract
Background: Globally, subsistence-level societies are experiencing rapid urbanization and concomitant increases in cardiometabolic diseases. Generalized measures to quantify lifestyle transitions will facilitate the identification of the most potent drivers of changing health within and between populations, enabling the identification of vulnerable communities, and aiding in the creation of effective policies to minimize disease. Methods: We developed ten scales Results: Cardiometabolic health was best predicted by measures that quantified urban infrastructure and market-derived material wealth compared to metrics encompassing diet, mobility, or acculturation, and these results were highly consistent across Turkana and Orang Asli and across sexes. Factor analysis results were also highly consistent between the two groups, revealing that lifestyle variation decomposes into two distinct axes-representing the built environment and diet-which change at different paces and have different relationships with health. Conclusion: Our analyses revealed surprising generalizability: in both the Turkana and Orang Asli, measures of local infrastructure and built environment better predicted cardiometabolic health than other facets of lifestyle that are seemingly more proximate to health, such as diet. We hypothesize that this is because the built environment impacts unmeasured proximate drivers like physical activity and broader access to market goods, and because it serves as a proxy of duration of market integration. Our results support the usage of relatively simple and easy to characterize features of the built environment as a cross-cultural tool in the investigation of lifestyle impacts on cardiometabolic health. Lay Summary: Worldwide, Indigenous and subsistence-level societies are undergoing rapid urbanization, industrialization, and market integration. To facilitate comparative and within-population analyses of resulting changes in health, we developed ten scales that quantify different features of lifestyle change that occur during this transition. We find that cardiovascular and metabolic health were most strongly explained by measures of the built environment, and these findings were highly consistent across two groups-the Turkana of Kenya and Orang Asli of Peninsular Malaysia-living in highly different environments and experiencing distinct pathways to industrialization.
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