Evidence map›Paper›PMID 42339315›Full record

ArticlemicroLife2026

Predicted bacterial uRBSs reveal translational coupling and ribosome-mediated RBS occlusion as gene-controlling mechanisms.

Theresa Dietz, Julian M Hahnfeld, Sophie Neumann, Yonca A Reinsch, Tessa Wenz, Susanne Barth-Weber, Jochen Blom, Alexander Goesmann, Elena Evguenieva-Hackenberg

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in microLife, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Theresa DietzInstitute of Microbiology and Molecular Biology, Justus-Liebig-University, 35392 Giessen, Germany.
Julian M HahnfeldBioinformatics and Systems Biology, Justus-Liebig-University, 35392 Giessen, Germany.ORCID https://orcid.org/0000-0002-8784-9773
Sophie NeumannInstitute of Microbiology and Molecular Biology, Justus-Liebig-University, 35392 Giessen, Germany.
Yonca A ReinschInstitute of Microbiology and Molecular Biology, Justus-Liebig-University, 35392 Giessen, Germany.
Tessa WenzInstitute of Microbiology and Molecular Biology, Justus-Liebig-University, 35392 Giessen, Germany.
Susanne Barth-WeberInstitute of Microbiology and Molecular Biology, Justus-Liebig-University, 35392 Giessen, Germany.
Jochen BlomBioinformatics and Systems Biology, Justus-Liebig-University, 35392 Giessen, Germany.ORCID https://orcid.org/0000-0001-6455-3622
Alexander GoesmannBioinformatics and Systems Biology, Justus-Liebig-University, 35392 Giessen, Germany.ORCID https://orcid.org/0000-0002-7086-2568
Elena Evguenieva-HackenbergInstitute of Microbiology and Molecular Biology, Justus-Liebig-University, 35392 Giessen, Germany.ORCID https://orcid.org/0000-0001-7270-3168

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Upstream open reading frames (uORFs) in the 5' leader of bacterial mRNAs can modulate gene expression, yet genome-wide identification remains limited. We combined bioinformatic prediction of ribosome-binding sites (RBSs)-a Shine-Dalgarno sequence and a start codon-with experimental validation to uncover new uORFs in

Indexed as

alphaproteobacteriamRNA leaderribosome binding site occlusionSinorhizobium melilotismall open reading frametranslational couplingupstream open reading frameupstream ribosome binding siteupstream Shine–Dalgarno sequence

Identifiers

PMID42339315
PMCPMC13285730

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.