ArticleFrontiers in pediatrics2026
Impulse oscillometry values calibrated against spirometric obstruction in children with suspected asthma.
Article in Frontiers in pediatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: The impulse oscillation system (IOS) requires less cooperation than spirometry for assessing obstructive lung disease in children aged 6-18 years; however, diagnostic criteria for several IOS parameters remain controversial. This study compared IOS and spirometry to determine IOS parameter cutoff values for spirometry-detectable airway obstruction in children. Methods: Spirometry was used as the reference standard. We enrolled 722 children with suspected asthma. Airway obstruction was defined as a ≥ 12% increase in FEV₁ after bronchodilator or any abnormal spirometric value (FEV₁ < 80% predicted, FEV₁/FVC <80%, or FEF parameters (MMEF, FEF₂₅-₇₅, etc.) < 56% predicted. IOS parameters (R5, X5, AX, Fres and R5-R20) were recorded. Results: Spirometry and IOS parameters were significantly correlated, R5-R20 correlated the strongest with FEV1 and MMEF. The suggestive AX and Fres cutoff values were 1.54 kPa·L⁻ Conclusion: Our study compared pre- and post-bronchodilator IOS and spirometry results and identified which IOS values correspond to spirometric obstruction.
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